抗原激活的及抗原特异性人类B淋巴细胞的鉴定、纯化与特性分析。
Identification, purification, and characterization of antigen-activated and antigen-specific human B lymphocytes.
作者信息
Kehrl J H, Fauci A S
出版信息
J Exp Med. 1983 May 1;157(5):1692-7. doi: 10.1084/jem.157.5.1692.
Abstract
Activated pneumococcal polysaccharide (PPS)-specific human B lymphocytes have been purified and examined in vitro. They are large cells that are refractory to further activation by antigen, anti-Ig, or Staphylococcus aureus Cowan strain I, but they respond directly by proliferation to B cell growth factors. In addition, they express the isotype pattern of activated cells and a surface marker of activated lymphocytes called 4F2. Finally, they contain a subset of cells that spontaneously secrete PPS-specific antibody.
摘要
已对活化的肺炎球菌多糖（PPS）特异性人B淋巴细胞进行了纯化并在体外进行了检测。它们是大细胞，对抗原、抗Ig或金黄色葡萄球菌考恩I株的进一步活化具有抗性，但它们通过增殖直接对B细胞生长因子作出反应。此外，它们表达活化细胞的同种型模式以及一种称为4F2的活化淋巴细胞表面标志物。最后，它们包含一个自发分泌PPS特异性抗体的细胞亚群。
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