一种针对激活抗原4F2的单克隆抗体对人B细胞反应的调节作用
Modulation of human B cell responses by a monoclonal antibody to an activation antigen 4F2.
作者信息
Gerrard T L, Jurgensen C H, Fauci A S
出版信息
Clin Exp Immunol. 1984 Jul;57(1):155-62.
Antigen specific human antibody responses can be modulated in vitro by the addition of 4F2 antibody, a monoclonal antibody (MoAb) which recognizes an antigen on activated T cells and B cells. Specific antibody responses induced with the antigen are suppressed by the addition of 4F2. However, specific antibody responses induced with the polyclonal activator, pokeweed mitogen (PWM), are significantly enhanced by the addition of 4F2. Proliferative responses to both antigen and PWM are suppressed by the addition of 4F2. The enhancement of PWM stimulated responses by 4F2 is mediated by T cells. However, in the absence of T cells, 4F2 can directly inhibit antigen specific B cells. Polyclonal Ig production stimulated by PWM was also enhanced by 4F2. Thus, the immunomodulating effects of the 4F2 MoAb are the result of a balance of enhancement and suppression mediated at the T cell and the B cell level, respectively.
通过添加4F2抗体（一种识别活化T细胞和B细胞上抗原的单克隆抗体），可在体外调节抗原特异性人抗体反应。添加4F2可抑制由该抗原诱导的特异性抗体反应。然而，添加4F2可显著增强由多克隆激活剂商陆丝裂原（PWM）诱导的特异性抗体反应。添加4F2可抑制对抗原和PWM的增殖反应。4F2对PWM刺激反应的增强作用由T细胞介导。然而，在没有T细胞的情况下，4F2可直接抑制抗原特异性B细胞。4F2还增强了PWM刺激的多克隆Ig产生。因此，4F2单克隆抗体的免疫调节作用是分别在T细胞和B细胞水平介导的增强和抑制平衡的结果。
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