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交叉反应性抗原特异性T细胞克隆的分析。单个克隆对两种主要组织相容性复合体（MHC）和两种非MHC抗原的特异性识别。

Analysis of cross-reactive antigen-specific T cell clones. Specific recognition of two major histocompatibility complex (MHC) and two non-MHC antigens by a single clone.

作者信息

Ben-Nun A, Lando Z, Dorf M E, Burakoff S J

出版信息

J Exp Med. 1983 Jun 1;157(6):2147-53. doi: 10.1084/jem.157.6.2147.

DOI:10.1084/jem.157.6.2147
PMID:6189955
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187034/
Abstract

Two T cell clones, one specific for I-Es/d plus myelin basic protein (BP) and another specific for I-Ak plus influenza virus have been demonstrated to cross-react with DBA/2 cells. Genetic and serological analyses have shown that each clone recognizes its respective priming antigen in association with self-major histocompatibility complex (MHC) determinants and each recognizes DBA/2 minor H antigens in association with allo I-Ad MHC antigens. Further analysis of these clones suggests (a) that the allo I-Ad MHC epitopes recognized by these clones are not shared with self-I-A epitopes, (b) that the virus or BP antigens do not cross-react with DBA/2 minor H antigens, (c) that these clones recognize different determinants on the DBA/2 minor H antigens, and (d) that there is a requirement for a specific association between the different MHC antigens and the non-MHC antigens to stimulate these clones. This specific associative recognition argues strongly for the "altered self" hypothesis.

摘要

已证明两个T细胞克隆与DBA/2细胞发生交叉反应，其中一个克隆对I-Es/d加髓鞘碱性蛋白（BP）具有特异性，另一个克隆对I-Ak加流感病毒具有特异性。遗传和血清学分析表明，每个克隆识别与自身主要组织相容性复合体（MHC）决定簇相关的各自的致敏抗原，并且每个克隆识别与同种异体I-Ad MHC抗原相关的DBA/2次要组织相容性抗原。对这些克隆的进一步分析表明：（a）这些克隆识别的同种异体I-Ad MHC表位不与自身I-A表位共享；（b）病毒或BP抗原不与DBA/2次要组织相容性抗原发生交叉反应；（c）这些克隆识别DBA/2次要组织相容性抗原上的不同决定簇；（d）不同的MHC抗原与非MHC抗原之间需要特定的关联来刺激这些克隆。这种特异性关联识别有力地支持了“自身改变”假说。

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本文引用的文献

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Specificity of T-cell cones illustrates altered self hypothesis.T细胞克隆型的特异性说明了自身改变假说。
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Contribution of antigen-presenting cell major histocompatibility complex gene products to the specificity of antigen-induced T cell activation.抗原呈递细胞主要组织相容性复合体基因产物对抗原诱导的T细胞活化特异性的作用。
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The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis.能够介导自身免疫性脑脊髓炎的可克隆抗原特异性T淋巴细胞系的快速分离。
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Small subunit of I-A subregion antigens determines the allospecificity recognized by a monoclonal antibody.I-A亚区抗原的小亚基决定了单克隆抗体识别的同种特异性。
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Killer cells reactive to altered-self antigens can also be alloreactive.对改变的自身抗原产生反应的杀伤细胞也可能具有同种异体反应性。
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Fine specificity of a continuously growing killer cell clone specific for H-Y antigen.对H-Y抗原具有特异性的持续生长的杀伤细胞克隆的精细特异性。
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Major histocompatibility complex restricted cell-mediated immunity.主要组织相容性复合体限制的细胞介导免疫
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