Ilyas A A, Davison A N
J Neurol Sci. 1983 Apr;59(1):85-95. doi: 10.1016/0022-510x(83)90083-7.
Peripheral blood lymphocytes from patients with multiple sclerosis (MS), other neurological diseases and healthy controls were investigated for the presence of cell-mediated hypersensitivity to brain gangliosides and myelin basic protein using an active E-rosette assay. Sensitivity to myelin basic protein and gangliosides was found in MS patients in acute relapse and with progressive disease, whereas no sensitivity was found in MS patients in remission. Patients with other neurological diseases showed no response to gangliosides, but sensitization to myelin basic protein was found in a patient with leucoencephalopathy and in 4 of 6 stroke patients. Healthy controls did not respond to either antigen. In MS patients a positive correlation was seen between lymphocyte responses to myelin basic protein and to gangliosides. The data suggest that in comparison to gangliosides, myelin basic protein is a weaker stimulator of active rosette-forming cells. Moreover, cellular hypersensitivity to myelin basic protein is not MS-specific and may be present as a consequence of brain damage. However, cellular hypersensitivity to gangliosides appears to be more specific to MS and may be important in the pathogenesis of the disease.
利用活性E花环试验，对多发性硬化症（MS）患者、其他神经疾病患者及健康对照者的外周血淋巴细胞进行研究，以检测是否存在针对脑苷脂和髓鞘碱性蛋白的细胞介导超敏反应。在急性复发期和进展性疾病的MS患者中发现了对髓鞘碱性蛋白和脑苷脂的敏感性，而缓解期的MS患者未发现敏感性。其他神经疾病患者对脑苷脂无反应，但在一名白质脑病患者和6名中风患者中的4名中发现了对髓鞘碱性蛋白的致敏。健康对照者对两种抗原均无反应。在MS患者中，淋巴细胞对髓鞘碱性蛋白和脑苷脂的反应之间存在正相关。数据表明，与脑苷脂相比，髓鞘碱性蛋白是活性花环形成细胞的较弱刺激物。此外，对髓鞘碱性蛋白的细胞超敏反应并非MS所特有，可能是脑损伤的结果。然而，对脑苷脂的细胞超敏反应似乎对MS更具特异性，可能在该疾病的发病机制中起重要作用。
