就中枢神经系统和多发性硬化而言，病毒包膜糖脂会引发自身免疫吗？
Can viral envelope glycolipids produce auto-immunity, with reference to the CNS and multiple sclerosis?
作者信息
Webb H E, Fazakerley J K
出版信息
Neuropathol Appl Neurobiol. 1984 Jan-Feb;10(1):1-10. doi: 10.1111/j.1365-2990.1984.tb00335.x.
Abstract
Many viruses, with lipid envelopes derived from the host cell membranes, have been implicated in the aetiology of multiple sclerosis (MS), and epidemiological studies support an infectious agent. Alternatively the disease is thought by other workers to be auto-immune in nature, and recently much attention has been focused on immunological sensitivity to glycolipids in MS patients. In this paper it is proposed that CNS demyelination could arise in susceptible individuals (HLA type) from an immune response to glycolipids, triggered by the carrier effect of one or more enveloped neurotropic viruses.
摘要
许多病毒具有源自宿主细胞膜的脂质包膜，它们被认为与多发性硬化症（MS）的病因有关，流行病学研究也支持存在一种感染因子。另外，其他研究人员认为该疾病本质上是自身免疫性的，最近人们对MS患者对糖脂的免疫敏感性给予了极大关注。本文提出，在易感个体（特定的人类白细胞抗原类型）中，中枢神经系统脱髓鞘可能源于对糖脂的免疫反应，这种反应由一种或多种包膜嗜神经病毒的载体效应引发。
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Can viral envelope glycolipids produce auto-immunity, with reference to the CNS and multiple sclerosis?就中枢神经系统和多发性硬化而言，病毒包膜糖脂会引发自身免疫吗？
Neuropathol Appl Neurobiol. 1984 Jan-Feb;10(1):1-10. doi: 10.1111/j.1365-2990.1984.tb00335.x.
2
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Immunoelectron-microscopical labelling of glycolipids in the envelope of a demyelinating brain-derived RNA virus (Semliki Forest) by anti-glycolipid sera.用抗糖脂血清对脱髓鞘脑源性RNA病毒（Semliki森林病毒）包膜中的糖脂进行免疫电子显微镜标记。
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CNS pathogenesis following a dual viral infection with Semliki Forest (alphavirus) and Langat (flavivirus).塞姆利基森林病毒（甲病毒属）和兰加特病毒（黄病毒属）双重病毒感染后的中枢神经系统发病机制。
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Semliki Forest virus-induced, immune-mediated demyelination: adoptive transfer studies and viral persistence in nude mice.塞姆利基森林病毒诱导的免疫介导脱髓鞘：裸鼠中的过继转移研究及病毒持续性
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Immunoelectron microscopical labelling of a glycolipid in the envelopes of brain cell-derived budding viruses, Semliki Forest, influenza and measles, using a monoclonal antibody directed chiefly against galactocerebroside resulting from Semliki Forest virus infection.利用一种主要针对因塞姆利基森林病毒感染产生的半乳糖脑苷脂的单克隆抗体，对源自脑细胞的出芽病毒（塞姆利基森林病毒、流感病毒和麻疹病毒）包膜中的一种糖脂进行免疫电子显微镜标记。
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Ital J Neurol Sci. 1984 Dec;5(4):347-56. doi: 10.1007/BF02042616.
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Do human T-lymphotrophic viruses (HTLVs) and other enveloped viruses induce autoimmunity in multiple sclerosis?人类嗜T淋巴细胞病毒（HTLVs）及其他包膜病毒会引发多发性硬化症中的自身免疫吗？
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本文引用的文献
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Ganglioside syndrome, a new autoimmune neurologic disorder, experimentally induced with brain gangliosides.神经节苷脂综合征，一种新型自身免疫性神经疾病，由脑内神经节苷脂实验性诱发。
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4
Anti-ganglioside antibodies in multiple sclerosis.多发性硬化症中的抗神经节苷脂抗体。
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5
Induction of antimyelin and antioligodendrocyte antibodies by vaccinia virus. An experimental study in the mouse.痘苗病毒诱导抗髓磷脂和抗少突胶质细胞抗体。小鼠实验研究。
J Neuroimmunol. 1981 Mar;1(1):117-24. doi: 10.1016/0165-5728(81)90014-x.
6
Abnofmalities in brain myelin or rabbits with experimental autoimmune multiple sclerosis-like disease induced by immunization to gangliosides.脑髓鞘异常或因接种神经节苷脂诱导出实验性自身免疫性多发性硬化样疾病的兔子。 （注：原英文文本“Abnofmalities”拼写错误，正确应为“Abnormalities”）
Acta Neurol Scand. 1982 Nov;66(5):568-74. doi: 10.1111/j.1600-0404.1982.tb03144.x.
7
Cyclosporin A inhibits ganglioside-stimulated lymphocyte rosette formation in multiple sclerosis.环孢素A抑制多发性硬化症中神经节苷脂刺激的淋巴细胞玫瑰花结形成。
Int Arch Allergy Appl Immunol. 1982;69(4):393-6. doi: 10.1159/000233206.
8
Elevated ganglioside concentration in serum and peripheral blood lymphocytes from multiple sclerosis patients in remission.缓解期多发性硬化症患者血清和外周血淋巴细胞中神经节苷脂浓度升高。
J Neurol Sci. 1982 Apr;54(1):143-8. doi: 10.1016/0022-510x(82)90226-x.
9
Multi-sialo brain gangliosides are powerful stimulators of active E-rosetting lymphocytes from multiple sclerosis patients.多唾液酸脑苷脂是来自多发性硬化症患者的活性E花环形成淋巴细胞的强效刺激剂。
J Neurol Sci. 1981 Nov-Dec;52(2-3):279-87. doi: 10.1016/0022-510x(81)90011-3.
10
Cyclosporin A blocks receptors for HLA-DR antigens on T cells.环孢素A可阻断T细胞上HLA - DR抗原的受体。
Nature. 1981 Apr 30;290(5809):792-4. doi: 10.1038/290792a0.
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