Zaffaroni M, Caputo D, Cazzullo C L
J Neurol. 1983;229(1):55-60. doi: 10.1007/BF00313496.
Cerebrospinal fluid (CSF) and serum samples from patients with multiple sclerosis and other neurological diseases were examined by capillary isotachophoresis (ITP). The percentage and the rate of synthesis of CSF IgG which migrated slowly with ITP were calculated. CSF specimens of most patients with multiple sclerosis contained increased percentages of slowly migrating IgG (slow IgG), corresponding to IgG oligoclonal bands in the "high-alkaline" region on isoelectric focusing. The patients with multiple sclerosis were found to have increased intrathecal synthesis of slow IgG, which correlated closely with the rate of intrathecal CNS IgG synthesis calculated by Tourtellotte's formula.
采用毛细管等速电泳（ITP）对多发性硬化症患者及其他神经系统疾病患者的脑脊液（CSF）和血清样本进行检测。计算脑脊液中免疫球蛋白G（IgG）经ITP缓慢迁移的百分比和合成速率。大多数多发性硬化症患者的脑脊液样本中，缓慢迁移的IgG（慢IgG）百分比升高，这与等电聚焦“高碱性”区域的IgG寡克隆带相对应。研究发现，多发性硬化症患者鞘内慢IgG合成增加，这与通过图尔泰洛公式计算的鞘内中枢神经系统IgG合成速率密切相关。
