Link H
Riv Patol Nerv Ment. 1976 Nov-Dec;97(6):323-40.
The IgG index (formula: see text) corrects for the influence of serum protein abnormalities as well as a bloodbrain barrier damage and is, therefore, a better measure for the presence of an IgG elevation in CSF due to IgG synthesis, when compared with other IgG quotients commonly used. Agar gel electrophoresis of CSF for demonstration of oligoclonal IgG is probably superior to the determination of the IgG index when a diagnosis of MS is suspected. Determination of kappa and lambda light chain antigenic determinants in CSF, and calculation of the kappa/lambda ratio may also be used to demonstrate the occurrence of oligoclonal CSF immunoglobulins. An abnormal ratio can, however, be demonstrated only in 50% of MS patients and has, therefore, at present no place as a routine diagnostic method when MS is suspected.
IgG指数（公式：见正文）校正了血清蛋白异常以及血脑屏障损伤的影响，因此，与常用的其他IgG商数相比，它是检测脑脊液中由于IgG合成导致IgG升高的更好指标。当怀疑患有多发性硬化症（MS）时，脑脊液琼脂凝胶电泳显示寡克隆IgG可能比IgG指数测定更具优势。测定脑脊液中κ和λ轻链抗原决定簇以及计算κ/λ比值也可用于证明脑脊液中寡克隆免疫球蛋白的存在。然而，只有50%的MS患者能显示出异常比值，因此，目前在怀疑MS时，它不作为常规诊断方法。
