Kilejian A
J Parasitol. 1983 Apr;69(2):257-61.
Rabbits were immunized with the histidine-rich protein (HRP) of the avian malaria parasite, Plasmodium lophurae. The anti-HRP immunoprecipitated the knob protein (KP) from extracts of the human parasite, Plasmodium falciparum. The anti-HRP did not react with any antigens of a laboratory-derived strain of P. falciparum (K-) that does not form knobs. Antisera raised against a membrane-enriched fraction of P. falciparum-infected erythrocytes as well as sera from humans exposed to P. falciparum infections immunoprecipitated HRP from P. lophurae extracts.
用禽疟原虫——洛氏疟原虫富含组氨酸的蛋白（HRP）对兔子进行免疫。抗HRP抗体从人类疟原虫——恶性疟原虫的提取物中免疫沉淀出了瘤状蛋白（KP）。抗HRP抗体不与实验室衍生的不形成瘤状物的恶性疟原虫菌株（K-）的任何抗原发生反应。针对恶性疟原虫感染红细胞的富含膜的部分产生的抗血清以及来自暴露于恶性疟原虫感染的人类的血清，从洛氏疟原虫提取物中免疫沉淀出了HRP。
