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来自约氏疟原虫的富含组氨酸蛋白与恶性疟原虫感染的红细胞膜上的瘤状突起相关蛋白之间的同源性。

Homology between a histidine-rich protein from Plasmodium lophurae and a protein associated with the knob-like protrusions on membranes of erythrocytes infected with Plasmodium falciparum.

作者信息

Kilejian A

出版信息

J Exp Med. 1980 Jun 1;151(6):1534-8. doi: 10.1084/jem.151.6.1534.

DOI:10.1084/jem.151.6.1534
PMID:6991629
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2185886/
Abstract

The incorporation of several radioactive amino acids into the knob protein of Plasmodium falciparum was compared. Histidine showed better incorporation than proline. A protein hydrolysate, which had all major amino acids except histidine and methionine, showed relatively poor incorporation as compared with proline, and no labeling could be detected with methionine or leucine. These results strongly suggest that the amino acid composition of the knob protein has the same peculiarities as that of a histidine-rich protein characterized from P. lophurae. Immunoelectron microscopy suggested possible immunological cross-reactivity between these two proteins.

摘要

对几种放射性氨基酸掺入恶性疟原虫的结节蛋白的情况进行了比较。组氨酸的掺入情况比脯氨酸更好。一种蛋白质水解产物，除了组氨酸和蛋氨酸外含有所有主要氨基酸，与脯氨酸相比其掺入情况相对较差，并且用蛋氨酸或亮氨酸检测不到标记。这些结果有力地表明，结节蛋白的氨基酸组成与从洛氏疟原虫鉴定出的富含组氨酸的蛋白质具有相同的特性。免疫电子显微镜显示这两种蛋白质之间可能存在免疫交叉反应性。

相似文献

1
Homology between a histidine-rich protein from Plasmodium lophurae and a protein associated with the knob-like protrusions on membranes of erythrocytes infected with Plasmodium falciparum.来自约氏疟原虫的富含组氨酸蛋白与恶性疟原虫感染的红细胞膜上的瘤状突起相关蛋白之间的同源性。
J Exp Med. 1980 Jun 1;151(6):1534-8. doi: 10.1084/jem.151.6.1534.
2
Immunological cross-reactivity of the histidine-rich protein of Plasmodium lophurae and the knob protein of Plasmodium falciparum.洛氏疟原虫富含组氨酸蛋白与恶性疟原虫结节蛋白的免疫交叉反应性。
J Parasitol. 1983 Apr;69(2):257-61.
3
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6
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Knob-positive and knob-negative Plasmodium falciparum differ in expression of a strain-specific malarial antigen on the surface of infected erythrocytes.knob阳性和knob阴性的恶性疟原虫在感染红细胞表面的菌株特异性疟疾抗原表达上存在差异。
J Exp Med. 1984 Nov 1;160(5):1585-90. doi: 10.1084/jem.160.5.1585.

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本文引用的文献

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Plasmodium falciparum malaria. Ultrastructure of parasitized erythrocytes in cardiac vessels.恶性疟原虫疟疾。心脏血管中被寄生红细胞的超微结构。
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Histidine-rich protein as a model malaria vaccine.
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Plasmodium falciparum and Plasmodium coatneyi: immunogenicity of "knob-like protrusions" on infected erythrocyte membranes.恶性疟原虫和科氏疟原虫：感染红细胞膜上“瘤状突起”的免疫原性。
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Characterization of a protein correlated with the production of knob-like protrusions on membranes of erythrocytes infected with Plasmodium falciparum.一种与恶性疟原虫感染的红细胞膜上瘤状突起产生相关的蛋白质的特性分析。
Proc Natl Acad Sci U S A. 1979 Sep;76(9):4650-3. doi: 10.1073/pnas.76.9.4650.
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A histidine-rich protein from Plasmodium falciparum and its interaction with membranes.一种来自恶性疟原虫的富含组氨酸的蛋白质及其与膜的相互作用。
Bull World Health Organ. 1977;55(2-3):191-7.