来自约氏疟原虫的富含组氨酸蛋白与恶性疟原虫感染的红细胞膜上的瘤状突起相关蛋白之间的同源性。
Homology between a histidine-rich protein from Plasmodium lophurae and a protein associated with the knob-like protrusions on membranes of erythrocytes infected with Plasmodium falciparum.
作者信息
Kilejian A
出版信息
J Exp Med. 1980 Jun 1;151(6):1534-8. doi: 10.1084/jem.151.6.1534.
Abstract
The incorporation of several radioactive amino acids into the knob protein of Plasmodium falciparum was compared. Histidine showed better incorporation than proline. A protein hydrolysate, which had all major amino acids except histidine and methionine, showed relatively poor incorporation as compared with proline, and no labeling could be detected with methionine or leucine. These results strongly suggest that the amino acid composition of the knob protein has the same peculiarities as that of a histidine-rich protein characterized from P. lophurae. Immunoelectron microscopy suggested possible immunological cross-reactivity between these two proteins.
摘要
对几种放射性氨基酸掺入恶性疟原虫的结节蛋白的情况进行了比较。组氨酸的掺入情况比脯氨酸更好。一种蛋白质水解产物，除了组氨酸和蛋氨酸外含有所有主要氨基酸，与脯氨酸相比其掺入情况相对较差，并且用蛋氨酸或亮氨酸检测不到标记。这些结果有力地表明，结节蛋白的氨基酸组成与从洛氏疟原虫鉴定出的富含组氨酸的蛋白质具有相同的特性。免疫电子显微镜显示这两种蛋白质之间可能存在免疫交叉反应性。
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