Ortega de la Cruz C, Fernández Gallardo L C, Damas Fernández-Figares M, García Martínez E
Servicio de Farmacia, Hospital Materno-Infantil, Málaga, España.
Nutr Hosp. 1993 Feb;8(2):105-8.
The physical and chemical compatibility of an enteral diet (standard Precitene) with a series of liquid preparations included in the hospital's formulary was evaluated. These preparations are included in the following groups: vitamins, antibiotics and chemotherapeutic drugs, analgesics, antiepileptic drugs, neuroleptics, bronchodilators, expectorants, antihistamines, immunosuppressors and short chain triglycerides. Phase separation, particle growth pH variation, osmolality increase and viscosity increase were studied. The results obtained indicate that the majority of the drugs studied are compatible from a physical and chemical point of view with the enteral diet used, at least during a 24 hour period, with the exception of those drugs which, because of their pH, acidify the mixture, causing problems of increased viscosity and particle growth, and of those liquid preparations of continuous oleous phase where phase separation is unavoidable. Lastly, a series of recommendations are given on cases where joint administration of drugs with enteral nutrition is suitable.
评估了一种肠内营养制剂（标准普瑞新）与医院处方集里一系列液体制剂的物理和化学相容性。这些制剂分为以下几类：维生素、抗生素和化疗药物、镇痛药、抗癫痫药、抗精神病药、支气管扩张剂、祛痰剂、抗组胺药、免疫抑制剂和短链甘油三酯。研究了相分离、颗粒生长、pH值变化、渗透压升高和粘度增加情况。所得结果表明，从物理和化学角度来看，所研究的大多数药物与所用的肠内营养制剂相容，至少在24小时内是如此，但那些因其pH值会使混合物酸化、导致粘度增加和颗粒生长问题的药物，以及那些连续油相液体制剂（相分离不可避免）除外。最后，针对适合将药物与肠内营养联合给药的情况给出了一系列建议。
