Falus A, Wiik A, Permin H, Brandslund I, Svehag S E
Arthritis Rheum. 1983 Jun;26(6):721-7. doi: 10.1002/art.1780260604.
Serum beta-2-microglobulin (beta 2m) levels, incidence and levels of anti-beta 2m autoantibodies, and quantity of circulating macromolecular complexes containing beta 2m were studied in patients with Felty's syndrome (FS), joint-restricted rheumatoid arthritis (RA), and healthy controls. The serum beta 2m concentrations detected in the FS group (6.95 +/- 2.9 mg/liter) greatly exceeded those of the RA group (3.4 +/- 1.2 mg/liter) and the control group (1.42 +/- 0.69 mg/liter). Autoantibodies to beta 2m were frequent in the FS group. Circulating complexes containing beta 2m, prepared by precipitation in 3% polyethylene glycol, were detected in 65% of FS and 35% of RA patients. In the majority of these cases the solid-phase C1q purified immune complexes also contained beta 2m. Detection of anti-beta 2m antibodies in a significant part of complexes containing beta 2m suggests the presence of specific immune complexes in this fraction of FS and RA patients.
对费尔蒂综合征（FS）患者、关节受限型类风湿关节炎（RA）患者及健康对照者的血清β2微球蛋白（β2m）水平、抗β2m自身抗体的发生率及水平，以及含β2m的循环大分子复合物的量进行了研究。FS组检测到的血清β2m浓度（6.95±2.9毫克/升）大大超过RA组（3.4±1.2毫克/升）和对照组（1.42±0.69毫克/升）。FS组中β2m自身抗体很常见。通过在3%聚乙二醇中沉淀制备的含β2m的循环复合物在65%的FS患者和35%的RA患者中被检测到。在大多数这些病例中，固相C1q纯化免疫复合物也含有β2m。在含β2m的复合物的很大一部分中检测到抗β2m抗体，这表明在这部分FS和RA患者中存在特异性免疫复合物。
