Permin H, Egeskjold E M
Allergy. 1982 Aug;37(6):421-7. doi: 10.1111/j.1398-9995.1982.tb02321.x.
Anti-IgG antibodies (anti-IgG) of the IgE class were studied in sera from patients with juvenile rheumatoid arthritis (JRA), rheumatoid arthritis (RA) and patients with Felty's syndrome (FS) by use of an indirect immunofluorescence technique. Forty-two per cent of 26 patients with JRA had IgE anti-IgG in serum all in low titers. Positive reactions prevailed in patients with multiple joint involvement. Sixty-three per cent of 30 patients with RA and 80% of 20 patients with FS had IgE anti-IgG, the titers found in FS patients being significantly higher. In JRA and FS patients the IgE anti-IgG titers were correlated to the titers of anti-IgG of the IgG class, and for FS patients also with the IgM and IgA classes of anti-IgG. In six of 10 patients with RA the synovial fluid samples from both knees contained IgE anti-IgG. In four of these patients the titers of IgE anti-IgG were higher than in the corresponding serum sample, pointing to a local production. After G-200 Sephadex chromatography IgE anti-IgG were demonstrated in the void volume indicating the presence of these autoantibodies in immune complexes. IgE anti-IgG may be involved in the pathogenesis of JRA and RA by eliciting Type I and III reactions.
采用间接免疫荧光技术，对青少年类风湿性关节炎（JRA）、类风湿性关节炎（RA）患者以及费尔蒂综合征（FS）患者血清中的IgE类抗IgG抗体（抗IgG）进行了研究。26例JRA患者中，42%血清中有IgE抗IgG，且均为低滴度。多关节受累患者中阳性反应更为常见。30例RA患者中有63%、20例FS患者中有80%存在IgE抗IgG，FS患者中发现的滴度显著更高。在JRA和FS患者中，IgE抗IgG滴度与IgG类抗IgG滴度相关，对于FS患者，还与IgM和IgA类抗IgG相关。10例RA患者中有6例双膝的滑液样本中含有IgE抗IgG。其中4例患者的IgE抗IgG滴度高于相应血清样本，表明存在局部产生。经G - 200 Sephadex柱层析后，在空体积中检测到IgE抗IgG，表明这些自身抗体存在于免疫复合物中。IgE抗IgG可能通过引发I型和III型反应参与JRA和RA的发病机制。
