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由H-2基因指导的T细胞所识别的胰岛素决定簇的结构分析。

Structural analysis of insulin determinants seen by T cells directed by H-2 genes.

作者信息

Talmon J, Ranghino G, Yonath A, Cohen I R

出版信息

Immunogenetics. 1983;18(1):79-89. doi: 10.1007/BF00401358.

DOI:10.1007/BF00401358
PMID:6190746
Abstract

The magnitude of the immune response of lymphocytes to defined antigenic determinants of ungulate insulins is controlled by the products of H-2 genes. Based on the crystallographically solved structure of porcine insulin, the close homology of all the ungulate insulins, and the amino acid substitutions, we built models of the different insulins. We analyzed the likely conformations of the antigenic determinants, and proposed structural specificities accounting for the immunologic phenomena observed.

摘要

淋巴细胞对有蹄类胰岛素特定抗原决定簇的免疫反应强度由H - 2基因的产物控制。基于猪胰岛素晶体学解析结构、所有有蹄类胰岛素的高度同源性以及氨基酸取代情况，我们构建了不同胰岛素的模型。我们分析了抗原决定簇可能的构象，并提出了解释所观察到的免疫现象的结构特异性。

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Structural analysis of insulin determinants seen by T cells directed by H-2 genes.由H-2基因指导的T细胞所识别的胰岛素决定簇的结构分析。
Immunogenetics. 1983;18(1):79-89. doi: 10.1007/BF00401358.
2
Immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin.免疫反应基因对胰岛素抗原性外来和自身决定簇的选择具有可变影响。
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3
H-2 genetic control of the response of T lymphocytes to insulins. Priming of nonresponder mice by forbidden variants of specific antigenic determinants.T淋巴细胞对胰岛素反应的H-2基因控制。通过特定抗原决定簇的禁忌变体对无反应小鼠进行致敏。
Eur J Immunol. 1980 Apr;10(4):284-9. doi: 10.1002/eji.1830100412.
4
Regulatory mechanisms of the immune response to heterologous insulins. I. Development and regulation of plaque-forming cell responses in vitro.
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5
Recognition of human insulin in vitro by T cells from subjects treated with animal insulins.用动物胰岛素治疗的受试者的T细胞在体外对人胰岛素的识别。
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Immune response gene control of determinant selection. II. Genetic control of the murine T lymphocyte proliferative response to insulin.决定簇选择的免疫反应基因控制。II. 小鼠T淋巴细胞对胰岛素增殖反应的遗传控制。
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T-lymphocyte response to cytochrome c. I. Demonstration of a T-cell heteroclitic proliferative response and identification of a topographic antigenic determinant on pigeon cytochrome c whose immune recognition requires two complementing major histocompatibility complex-linked immune response genes.T淋巴细胞对细胞色素c的反应。I. T细胞异质性增殖反应的证明以及对鸽细胞色素c上一个拓扑抗原决定簇的鉴定，其免疫识别需要两个互补的主要组织相容性复合体连锁免疫反应基因。
J Exp Med. 1979 Oct 1;150(4):830-48. doi: 10.1084/jem.150.4.830.

引用本文的文献

1
T cell Ir phenotype modified by excising primary antigen deposit.通过切除原发性抗原沉积物改变的T细胞Ir表型
Immunogenetics. 1984;19(5):449-54. doi: 10.1007/BF00364647.
2
Recognition of human insulin in vitro by T cells from subjects treated with animal insulins.用动物胰岛素治疗的受试者的T细胞在体外对人胰岛素的识别。
J Clin Invest. 1985 Dec;76(6):2070-7. doi: 10.1172/JCI112210.
3
Identification of an autologous insulin B chain peptide as a target antigen for H-2Kb-restricted cytotoxic T lymphocytes.鉴定一种自体胰岛素B链肽作为H-2Kb限制性细胞毒性T淋巴细胞的靶抗原。

本文引用的文献

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Induction of T and B cell immunity by anti-idiotypic antibody.抗独特型抗体诱导T细胞和B细胞免疫
Eur J Immunol. 1975 Oct;5(10):661-6. doi: 10.1002/eji.1830051002.
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Responder T cells depleted of alloreactive cells react to antigen presented on allogeneic macrophages from nonresponder strains.去除同种异体反应性细胞的反应性T细胞会对来自无反应性品系的同种异体巨噬细胞所呈递的抗原产生反应。
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H-2 genetic control of the response of T lymphocytes to insulins. Priming of nonresponder mice by forbidden variants of specific antigenic determinants.T淋巴细胞对胰岛素反应的H-2基因控制。通过特定抗原决定簇的禁忌变体对无反应小鼠进行致敏。
Eur J Immunol. 1980 Apr;10(4):284-9. doi: 10.1002/eji.1830100412.
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Structure of a lambda-type Bence-Jones protein at 3.5-A resolution.分辨率为3.5埃的λ型本斯-琼斯蛋白的结构
Biochemistry. 1973 Nov 6;12(23):4620-31. doi: 10.1021/bi00747a013.
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Preparation and properties of crystals of a Bence-Jones dimer with mercury inserted into the interchain disulfide bond.
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The three dimensional structure of a combining region-ligand complex of immunoglobulin NEW at 3.5-A resolution.免疫球蛋白 NEW 结合区域 - 配体复合物在 3.5 埃分辨率下的三维结构。
Proc Natl Acad Sci U S A. 1974 Apr;71(4):1427-30. doi: 10.1073/pnas.71.4.1427.
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Structure of insulin in 4-zinc insulin.4-锌胰岛素中的胰岛素结构。
Nature. 1976 May 13;261(5556):166-8. doi: 10.1038/261166a0.
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Three-dimensional structure of immunoglobulins.
Annu Rev Biochem. 1975;44:639-67. doi: 10.1146/annurev.bi.44.070175.003231.
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Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin.胰岛素受体结合区域负协同性相关残基的定位
Nature. 1978 Jun 15;273(5663):504-9. doi: 10.1038/273504a0.