免疫反应基因对胰岛素抗原性外来和自身决定簇的选择具有可变影响。
Immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin.
作者信息
Cohen I R, Talmon J, Lev-Ram V, Ben-Nun A
出版信息
Proc Natl Acad Sci U S A. 1979 Aug;76(8):4066-70. doi: 10.1073/pnas.76.8.4066.
Abstract
We studied the proliferative response of mouse T lymphocytes to determinants on ungulate insulins. The immunopotency of defined determinants on the molecule was found to be regulated by three factors: the immune response genes of the immunized mouse, the mode of presentation of insulin on cells or in adjuvant, and the intramolecular cooperativity between different determinants on the insulin molecule. Autosensitization against self determinants was observed under specific conditions. These findings emphasize the variable expression of immune response genes.
摘要
我们研究了小鼠T淋巴细胞对有蹄类胰岛素上决定簇的增殖反应。发现分子上特定决定簇的免疫效力受三个因素调节：免疫小鼠的免疫反应基因、胰岛素在细胞上或佐剂中的呈递方式以及胰岛素分子上不同决定簇之间的分子内协同作用。在特定条件下观察到了针对自身决定簇的自身致敏现象。这些发现强调了免疫反应基因的可变表达。
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