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1
Immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin.免疫反应基因对胰岛素抗原性外来和自身决定簇的选择具有可变影响。
Proc Natl Acad Sci U S A. 1979 Aug;76(8):4066-70. doi: 10.1073/pnas.76.8.4066.
2
Structural analysis of insulin determinants seen by T cells directed by H-2 genes.由H-2基因指导的T细胞所识别的胰岛素决定簇的结构分析。
Immunogenetics. 1983;18(1):79-89. doi: 10.1007/BF00401358.
3
H-2 genetic control of the response of T lymphocytes to insulins. Priming of nonresponder mice by forbidden variants of specific antigenic determinants.T淋巴细胞对胰岛素反应的H-2基因控制。通过特定抗原决定簇的禁忌变体对无反应小鼠进行致敏。
Eur J Immunol. 1980 Apr;10(4):284-9. doi: 10.1002/eji.1830100412.
4
Immune response gene control of determinant selection. II. Genetic control of the murine T lymphocyte proliferative response to insulin.决定簇选择的免疫反应基因控制。II. 小鼠T淋巴细胞对胰岛素增殖反应的遗传控制。
J Immunol. 1979 Jul;123(1):471-6.
5
T-lymphocyte response to cytochrome c. I. Demonstration of a T-cell heteroclitic proliferative response and identification of a topographic antigenic determinant on pigeon cytochrome c whose immune recognition requires two complementing major histocompatibility complex-linked immune response genes.T淋巴细胞对细胞色素c的反应。I. T细胞异质性增殖反应的证明以及对鸽细胞色素c上一个拓扑抗原决定簇的鉴定，其免疫识别需要两个互补的主要组织相容性复合体连锁免疫反应基因。
J Exp Med. 1979 Oct 1;150(4):830-48. doi: 10.1084/jem.150.4.830.
6
Delineation of Ia:nominal antigen complementary determinants recognized by T cells in studies of gene complementation in response to insulin.Ia的描绘：在胰岛素反应基因互补研究中T细胞识别的名义抗原互补决定簇。
J Immunol. 1984 Jan;132(1):303-9.
7
Genetic control of the immune response to insulin: its dependence upon a macrophage mediated selection of distinct antigenic sites.对胰岛素免疫反应的遗传控制：其依赖于巨噬细胞介导的对不同抗原位点的选择。
Adv Exp Med Biol. 1978;98:447-58. doi: 10.1007/978-1-4615-8858-0_26.
8
Specificity of T cell clones for antigen and autologous major histocompatibility complex products determines specificity for foreign major histocompatibility complex products.T细胞克隆对抗原和自体主要组织相容性复合体产物的特异性决定了对异体主要组织相容性复合体产物的特异性。
J Exp Med. 1983 Aug 1;158(2):428-37. doi: 10.1084/jem.158.2.428.
9
B cell activation potential of insulin-reactive T cells in H-2b mice.H-2b小鼠中胰岛素反应性T细胞的B细胞激活潜能
Eur J Immunol. 1984 Dec;14(12):1106-10. doi: 10.1002/eji.1830141208.
10
Assessment of the role of determinant selection in genetic control of the immune response to insulin in H-2b mice.对决定簇选择在H-2b小鼠对胰岛素免疫反应的遗传控制中的作用的评估。
J Immunol. 1999 Sep 1;163(5):2549-54.

引用本文的文献

1
Xid-defective male (CBA/N X C57BL/6)F1 accessory cells present bovine insulin to long-term cultured F1-restricted T-cells.Xid缺陷雄性（CBA/N×C57BL/6）F1辅助细胞将牛胰岛素呈递给长期培养的F1限制性T细胞。
Immunogenetics. 1982;16(3):219-27. doi: 10.1007/BF00343311.
2
Mutations at H-2K or H-2D alter immune response phenotype of autoimmune thyroiditis.H-2K或H-2D处的突变会改变自身免疫性甲状腺炎的免疫反应表型。
Immunogenetics. 1982;15(6):625-7. doi: 10.1007/BF00347059.
3
Analysis of the in vitro immune response to insulin. I. Primary induction of insulin-specific T helper cells and characterization of the genetic control of the helper cell response to bovine and porcine insulin.胰岛素体外免疫反应分析。I.胰岛素特异性T辅助细胞的初次诱导以及对牛胰岛素和猪胰岛素辅助细胞反应的遗传控制特征
Immunology. 1980 Jul;40(3):385-94.
4
T cell Ir phenotype modified by excising primary antigen deposit.通过切除原发性抗原沉积物改变的T细胞Ir表型
Immunogenetics. 1984;19(5):449-54. doi: 10.1007/BF00364647.
5
Molecular events in the processing of avidin by antigen-presenting cells (APC). III. Activation of T-lymphocyte lines and H-2 restriction are mediated by processed avidin associated with I-region gene products.抗原呈递细胞（APC）处理抗生物素蛋白过程中的分子事件。III. 与I区基因产物相关的经处理抗生物素蛋白介导T淋巴细胞系的激活和H-2限制性。
Immunogenetics. 1983;18(3):291-302. doi: 10.1007/BF00952967.
6
Thymic reconstitution of H-2-linked T-cell responses to thyroglobulin or insulin.H-2连锁的针对甲状腺球蛋白或胰岛素的T细胞反应的胸腺重建。
Immunogenetics. 1983;17(1):95-100. doi: 10.1007/BF00364293.
7
Molecular events in the processing of avidin by antigen-presenting cells (APC). I. The immune response of T lymphocytes to avidin is regulated by H-2-linked Ir genes.抗原呈递细胞（APC）处理抗生物素蛋白过程中的分子事件。I. T淋巴细胞对抗生物素蛋白的免疫反应受H-2连锁Ir基因调控。
Immunogenetics. 1983;18(3):267-75. doi: 10.1007/BF00952965.
8
Molecular events in the processing of avidin by antigen-presenting cells (APC). II. Identical processing by APC of H-2 high- and low-responder mouse strains.抗原呈递细胞（APC）处理抗生物素蛋白过程中的分子事件。II. H-2高应答和低应答小鼠品系的APC进行相同处理
Immunogenetics. 1983;18(3):277-90. doi: 10.1007/BF00952966.
9
Structural analysis of insulin determinants seen by T cells directed by H-2 genes.由H-2基因指导的T细胞所识别的胰岛素决定簇的结构分析。
Immunogenetics. 1983;18(1):79-89. doi: 10.1007/BF00401358.
10
Reversal of H-2-restricted hyporesponsiveness to human growth hormone by the use of aluminum hydroxide as adjuvant.使用氢氧化铝作为佐剂逆转H-2限制的对人生长激素的低反应性。
Immunogenetics. 1985;21(5):505-9. doi: 10.1007/BF00430933.

本文引用的文献

1
Determinant selection is a macrophage dependent immune response gene function.决定簇选择是一种巨噬细胞依赖性免疫反应基因功能。
Nature. 1977 May 12;267(5607):156-8. doi: 10.1038/267156a0.
2
Mouse insulins--separation and structures.小鼠胰岛素——分离与结构
Int J Protein Res. 1971;3(3):149-55. doi: 10.1111/j.1399-3011.1971.tb01705.x.
3
Antigenic competition and genetic control of the immune response. A hypothesis for intramolecular competition.抗原竞争与免疫反应的遗传控制。关于分子内竞争的一种假说。
Cell Immunol. 1973 Aug;8(2):299-310. doi: 10.1016/0008-8749(73)90119-6.
4
Cellular analysis of the phenotypic correction of the genetically controlled low immune response to the polyproline determinant by macrophages.巨噬细胞对多聚脯氨酸决定簇遗传控制的低免疫反应进行表型校正的细胞分析。
Cell Immunol. 1974 May;12(2):271-9. doi: 10.1016/0008-8749(74)90079-3.
5
Autoimmune encephalomyelitis: activation of thymus lymphocytes against syngeneic brain antigens in vitro.自身免疫性脑脊髓炎：体外胸腺淋巴细胞针对同基因脑抗原的激活
Science. 1974 Mar 15;183(4129):1083-5. doi: 10.1126/science.183.4129.1083.
6
Varied effects of polyadenylic-polyuridylic acid on immune responses.聚腺苷酸-聚尿苷酸对免疫反应的多种影响。
Biochimie. 1976;58(1-2):173-7. doi: 10.1016/s0300-9084(76)80367-7.
7
Ir-gene control of antibody class production.Ir基因对抗体类别产生的控制。
J Immunol. 1977 Feb;118(2):427-30.
8
Mapping of the residues responsible for the negative cooperativity of the receptor-binding region of insulin.胰岛素受体结合区域负协同性相关残基的定位
Nature. 1978 Jun 15;273(5663):504-9. doi: 10.1038/273504a0.
9
Secondary antibody responses in vitro to L-glutamic acid60-L-alanine30-L-tyrosine10 (GAT) by (responder X nonresponder)F1 spleen cells stimulated by parental GAT-macrophages.亲本GAT-巨噬细胞刺激的（反应者X无反应者）F1脾细胞对L-谷氨酸60-L-丙氨酸30-L-酪氨酸10（GAT）的体外二次抗体反应。
J Exp Med. 1977 Dec 1;146(6):1827-32. doi: 10.1084/jem.146.6.1827.
10
Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells.决定簇选择的免疫反应基因控制。I. 豚鼠T细胞和B细胞识别的胰岛素上免疫原性位点的分子内定位。
J Exp Med. 1977 Mar 1;145(3):726-42. doi: 10.1084/jem.145.3.726.

免疫反应基因对胰岛素抗原性外来和自身决定簇的选择具有可变影响。

Immune response genes have a variable influence on the selection of antigenic foreign and self determinants of insulin.

作者信息

Cohen I R, Talmon J, Lev-Ram V, Ben-Nun A

出版信息

Proc Natl Acad Sci U S A. 1979 Aug;76(8):4066-70. doi: 10.1073/pnas.76.8.4066.

DOI:10.1073/pnas.76.8.4066
PMID:91175
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC383978/
Abstract

We studied the proliferative response of mouse T lymphocytes to determinants on ungulate insulins. The immunopotency of defined determinants on the molecule was found to be regulated by three factors: the immune response genes of the immunized mouse, the mode of presentation of insulin on cells or in adjuvant, and the intramolecular cooperativity between different determinants on the insulin molecule. Autosensitization against self determinants was observed under specific conditions. These findings emphasize the variable expression of immune response genes.

摘要

我们研究了小鼠T淋巴细胞对有蹄类胰岛素上决定簇的增殖反应。发现分子上特定决定簇的免疫效力受三个因素调节：免疫小鼠的免疫反应基因、胰岛素在细胞上或佐剂中的呈递方式以及胰岛素分子上不同决定簇之间的分子内协同作用。在特定条件下观察到了针对自身决定簇的自身致敏现象。这些发现强调了免疫反应基因的可变表达。