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Prospective study of gram-stained stool smears in diagnosis of Clostridium difficile colitis.革兰氏染色粪便涂片在艰难梭菌结肠炎诊断中的前瞻性研究。
J Clin Microbiol. 1983 May;17(5):906-8. doi: 10.1128/jcm.17.5.906-908.1983.
2
Clostridium difficile colitis: an efficient clinical approach to diagnosis.艰难梭菌结肠炎：一种高效的临床诊断方法。
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Clostridium difficile-associated diarrhea and colitis.艰难梭菌相关性腹泻和结肠炎
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Enzyme immunoassay for detection of Clostridium difficile toxins A and B in patients with antibiotic-associated diarrhoea and colitis.用于检测抗生素相关性腹泻和结肠炎患者艰难梭菌毒素A和B的酶免疫测定法。
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Discontinuous counterimmunoelectrophoresis in the diagnosis of antibiotic-associated colitis.间断对流免疫电泳在抗生素相关性结肠炎诊断中的应用
J Clin Gastroenterol. 1982 Jun;4(3):253-6. doi: 10.1097/00004836-198206000-00010.
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[Studies on Clostridium difficile and antimicrobial associated diarrhea or colitis].[艰难梭菌与抗菌药物相关性腹泻或结肠炎的研究]
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Optimal methods for identifying Clostridium difficile infections.鉴定艰难梭菌感染的最佳方法。
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Evaluation of a novel molecular assay to diagnose toxigenic strains of Clostridium difficile.评估一种新型分子检测方法用于诊断产毒艰难梭菌。
Anaerobe. 2018 Aug;52:111-114. doi: 10.1016/j.anaerobe.2018.06.012. Epub 2018 Jun 22.

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Culturing and maintaining Clostridium difficile in an anaerobic environment.在厌氧环境中培养和维持艰难梭菌。
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Persistent digestive disorders in the tropics: causative infectious pathogens and reference diagnostic tests.热带地区持续性消化紊乱：病因感染性病原体及参考诊断检测。
BMC Infect Dis. 2013 Jan 24;13:37. doi: 10.1186/1471-2334-13-37.
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Is Fecal Leukocyte Test a good predictor of Clostridium difficile associated diarrhea?粪便白细胞检测能否很好地预测艰难梭菌相关性腹泻？
Ann Clin Microbiol Antimicrob. 2006 Apr 19;5:9. doi: 10.1186/1476-0711-5-9.
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Toxin gene analysis of a variant strain of Clostridium difficile that causes human clinical disease.一株引起人类临床疾病的艰难梭菌变异菌株的毒素基因分析。
Infect Immun. 2000 Oct;68(10):5480-7. doi: 10.1128/IAI.68.10.5480-5487.2000.
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Detection of Clostridium difficile in faeces by direct gas liquid chromatography.通过直接气相色谱法检测粪便中的艰难梭菌。
J Clin Pathol. 1984 Feb;37(2):117-9. doi: 10.1136/jcp.37.2.117.

本文引用的文献

1
Clostridium difficile toxin.
Pharmacol Ther. 1981;13(3):441-52. doi: 10.1016/0163-7258(81)90025-5.
2
Clostridium difficile and its cytotoxin in feces of patients with antimicrobial agent-associated diarrhea and miscellaneous conditions.艰难梭菌及其细胞毒素在抗菌药物相关性腹泻及其他病症患者粪便中的情况。
J Clin Microbiol. 1982 Jun;15(6):1049-53. doi: 10.1128/jcm.15.6.1049-1053.1982.
3
Clostridia and antimicrobial enterocolitis.梭菌与抗菌药物相关性小肠结肠炎
Annu Rev Med. 1981;32:327-33. doi: 10.1146/annurev.me.32.020181.001551.
4
Colitis induced by Clostridium difficile.艰难梭菌引起的结肠炎。
Rev Infect Dis. 1979 Mar-Apr;1(2):370-8. doi: 10.1093/clinids/1.2.370.
5
Selective and differential medium for isolation of Clostridium difficile.用于分离艰难梭菌的选择性和鉴别性培养基。
J Clin Microbiol. 1979 Feb;9(2):214-9. doi: 10.1128/jcm.9.2.214-219.1979.

革兰氏染色粪便涂片在艰难梭菌结肠炎诊断中的前瞻性研究。

Prospective study of gram-stained stool smears in diagnosis of Clostridium difficile colitis.

作者信息

Shanholtzer C J, Peterson L R, Olson M N, Gerding D N

出版信息

J Clin Microbiol. 1983 May;17(5):906-8. doi: 10.1128/jcm.17.5.906-908.1983.

DOI:10.1128/jcm.17.5.906-908.1983
PMID:6190839
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC272763/
Abstract

Gram stains of stools from patients with diarrhea and control patients with no diarrhea were examined for a predominance of gram-positive rods and the presence of polymorphonuclear leukocytes. Results were compared with those from lower gastrointestinal endoscopy for pseudomembranes. Clostridium difficile culturing, and C. difficile toxin assay. The Gram stain was moderately difficult to interpret and was not useful in diagnosing diarrheal disease associated with C. difficile.

摘要

对腹泻患者及无腹泻对照患者的粪便进行革兰氏染色，检查革兰氏阳性杆菌的优势情况及多形核白细胞的存在情况。将结果与下消化道内镜检查发现假膜、艰难梭菌培养及艰难梭菌毒素检测的结果进行比较。革兰氏染色的结果较难解读，对诊断与艰难梭菌相关的腹泻病并无帮助。