Amornmarn R, Prempree T, Sewchand W, Jaiwatana J
Cancer. 1983 Sep 1;52(5):802-7. doi: 10.1002/1097-0142(19830901)52:5<802::aid-cncr2820520509>3.0.co;2-m.
During the period from 1957-1976, 70 patients with advanced malignant tumors of nasopharynx were treated by irradiation in the Department of Radiation Therapy, University of Maryland Hospital. Forty-nine patients were treated with curative intent and 21 patients with palliative purpose. Of 49 patients treated for cure, 22 (45%) survived disease-free for at least 5 years. Local control was achieved best (92%) by combined treatment, external beam and brachytherapy. Factors responsible for local control and disease-free survival, appear to be related to clinical staging (primary and nodal disease), cell types and treatment used. In spite of aggressive radiation treatment for advanced cases (Stages III and IV), distant disease is still a major problem and will necessitate further trial by combined chemotherapeutic treatment with irradiation. This article highlights the results and failures of the technique of the irradiation, both external and brachytherapy. It is suggested that aggressive radiation treatment using a combined approach (external beam and brachytherapy, whenever possible) be done in all cases for cure. Palliative treatment can only offer a short-term symptom-free status in 72% of all cases treated.
在1957年至1976年期间，马里兰大学医院放射治疗科对70例晚期鼻咽癌患者进行了放射治疗。49例患者接受了根治性治疗，21例患者接受了姑息性治疗。在49例接受根治性治疗的患者中，22例（45%）无病存活至少5年。联合治疗（外照射和近距离放疗）的局部控制效果最佳（92%）。影响局部控制和无病生存的因素似乎与临床分期（原发灶和淋巴结疾病）、细胞类型及所采用的治疗方法有关。尽管对晚期病例（Ⅲ期和Ⅳ期）进行了积极的放射治疗，但远处转移仍然是一个主要问题，需要进一步尝试放疗联合化疗。本文重点介绍了外照射和近距离放疗技术的治疗结果及不足之处。建议对所有病例尽可能采用联合方法（外照射和近距离放疗）进行积极的放射治疗以实现根治。姑息性治疗仅能使72%的治疗病例获得短期无症状状态。
