[Effect of aminazin on hydrolase activity of the blood and their excretion by the kidneys].

Chronic experiments in dogs revealed that 0.5 mg/kg of aminasin did not affect the content of pepsinogen, amylase and lipase in the peripheral blood plasma but somewhat increased the variability of the blood pepsinogen and lipase. 2 mg/kg of aminasin decreased the pepsinogen content in the blood; 5 mg/kg decreased the amylase level as well. Aminasin decreased the renal excretion of pepsinogen in direct proportion to its dosage. 5 mg/kg of aminasin decreased the renal excretion of amylase as well, with no considerable effect on the renal excretion of lipase. Aminasin (5 mg/kg) delayed the period of restoration of the blood level of amylase and pepsinogen administered parenterally, and intensified the disenzymemia caused by pepsinogen administration; the renal excretion of enzymes was decreased. The central nervous mechanisms responding to the above doses of aminasin are concluded to play a major role in maintaining the homeostasis of hydrolytic enzymes in the blood.