Brodin E, Sjölund K, Håkanson R, Sundler F
Gastroenterology. 1983 Sep;85(3):557-64.
The regional and topographic distribution of substance P-containing nerve fibers in the human and feline intestinal wall was studied by immunocytochemistry and radioimmunoassay. The concentration of substance P was measured in the different layers of the duodenum, jejunum, ileum, and colon. In both humans and cat, substance P fibers were fairly numerous, and the substance P concentration was comparatively high in the smooth muscle layer, including the myenteric ganglia. In humans, but not in cat, substance P fibers were numerous, and the substance P concentration was also high in the mucosa. Substance P-containing nerve cell bodies were observed in the myenteric ganglia of both species. In the submucous ganglia, such nerve cell bodies were seen in the human intestine only, suggesting that they represent the origin of the numerous mucosal substance P fibers in this species. Previous studies have revealed a relative paucity of substance P fibers in the intestinal mucosa of several mammals, such as mouse, rat, and pig. The cat can now be added to those having few mucosal substance P fibers, whereas humans seem to be notably rich in such fibers, suggesting that substance P may play a role in the regulation of mucosal functions in the human intestine.
采用免疫细胞化学和放射免疫分析法研究了人和猫肠壁中含P物质神经纤维的区域和局部分布。测定了十二指肠、空肠、回肠和结肠不同层中P物质的浓度。在人和猫中，P物质纤维都相当多，在包括肌间神经节在内的平滑肌层中，P物质浓度相对较高。在人类而非猫中，P物质纤维很多，且在黏膜中P物质浓度也很高。在这两个物种的肌间神经节中都观察到了含P物质的神经细胞体。在黏膜下神经节中，仅在人类肠道中见到此类神经细胞体，这表明它们是该物种中众多黏膜P物质纤维的起源。先前的研究表明，在几种哺乳动物如小鼠、大鼠和猪的肠黏膜中，P物质纤维相对较少。现在猫也可被归入黏膜P物质纤维较少的动物之列，而人类似乎富含此类纤维，这表明P物质可能在人类肠道黏膜功能的调节中发挥作用。
