Fuhrmann M, Hruby K, Gössinger H, Shroff D, Gassner B
Wien Med Wochenschr. 1983 Jun 15;133(11):283-6.
From 1975 to 1982, the Austrian Poison Information Centre gave medical advice in forty cases of acute melitracenee-flupenthixol poisoning. The case reports were reviewed and analysed in retrospect. 13 patients who either had ingested less than 20 pills (n = 5) or who underwent early gastric lavage (n = 8) showed no symptoms. In 19 patients who had swallowed 20 to 60 (n = 11), 60 to 100 (n = 3) pills respectively, or an unknown dose (n = 5) atropine like symptoms predominated. Five patients developed atropine like and extrapyramidal symptoms. The number of pills taken by these patients ranged from 20 to 60 (n = 4) and in one up to 100. Extrapyramidal reactions were encountered as predominant symptoms in three patients one of which had taken 20, the other 60 and the third an unknown number of pills. Additionally, five patients were unconscious. 21 patients developed ECG changes, 19 of which showing sinus tachycardia. The remaining two patients who had ingested 600 to 1000 mg melitracen atrial premature beats or T-wave inversions were observed. All 40 patients recovered.
1975年至1982年期间，奥地利中毒信息中心针对40例急性美利曲辛-氟哌噻吨中毒病例提供了医疗建议。对这些病例报告进行了回顾性审查和分析。13例患者要么摄入少于20片药物（n = 5），要么接受了早期洗胃（n = 8），均未出现症状。19例患者分别吞服了20至60片（n = 11）、60至100片（n = 3）药物，或服用了未知剂量药物（n = 5），以类似阿托品的症状为主。5例患者出现了类似阿托品的症状和锥体外系症状。这些患者服用的药片数量在20至60片之间（n = 4），其中1例服用了多达100片。锥体外系反应是3例患者的主要症状，其中1例服用了20片，另1例服用了60片，第3例服用的药片数量未知。此外，5例患者昏迷。21例患者出现心电图改变，其中19例表现为窦性心动过速。观察到另外2例摄入600至1000毫克美利曲辛的患者出现房性早搏或T波倒置。所有40例患者均康复。
