Assem E S, Bray K, Dawson P
Br J Radiol. 1983 Sep;56(669):647-52. doi: 10.1259/0007-1285-56-669-647.
The capacity of conventional and new low-osmolality contrast agents to stimulate histamine release from human basophils has been studied in vitro. When compared on an iodine concentration basis, the new agents release less histamine than the conventional agents at intermediate and higher concentration. However, the newer compounds exhibit a biphasic histamine release response to increasing iodine concentration with a low concentration peak, a phenomenon not previously described. Among the conventional ionic agents, meglumine salts were confirmed to be more potent histamine releasers than sodium salts. Possible mechanisms of this histamine release and the bearing of the findings on the safety of contrast media are discussed.
在体外研究了传统和新型低渗造影剂刺激人嗜碱性粒细胞释放组胺的能力。在碘浓度基础上进行比较时，新型造影剂在中等浓度和高浓度下释放的组胺比传统造影剂少。然而，新型化合物对碘浓度增加呈现双相组胺释放反应，有一个低浓度峰值，这是以前未描述过的现象。在传统离子型造影剂中，证实葡甲胺盐比钠盐更易释放组胺。讨论了这种组胺释放的可能机制以及这些发现对造影剂安全性的影响。
