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红细胞锂离子与血浆锂离子的比率。它们与血浆锂离子浓度有关吗?

Red blood cell Li+ to plasma Li+ ratios. Are they related to plasma Li+ concentrations?

作者信息

Brunswick D J, Frazer A, Mendels J, Ramsey T A

出版信息

Neuropsychobiology. 1978;4(2):121-7. doi: 10.1159/000117626.

DOI:10.1159/000117626
PMID:619303
Abstract

The relationship between the lithium ratio (ratio of lithium in blood cells to that in plasma) and plasma lithium concentration was examined in a group of male inpatients taking lithium carbonate for affective disorders. The lithium ratio was found to increase in the majority of these patients as plasma lithium concentration increased. However, the magnitude of variation of the lithium ratio with plasma lithium concentration observed in these patients is not sufficient to seriously affect the value of determining the lithium ratio in the clinical situation.

摘要

在一组因情感障碍而服用碳酸锂的男性住院患者中,研究了锂比率(血细胞中锂与血浆中锂的比率)与血浆锂浓度之间的关系。结果发现,随着血浆锂浓度的升高,这些患者中的大多数锂比率也会升高。然而,在这些患者中观察到的锂比率随血浆锂浓度的变化幅度,不足以严重影响在临床情况下测定锂比率的价值。

相似文献

1
Red blood cell Li+ to plasma Li+ ratios. Are they related to plasma Li+ concentrations?红细胞锂离子与血浆锂离子的比率。它们与血浆锂离子浓度有关吗?
Neuropsychobiology. 1978;4(2):121-7. doi: 10.1159/000117626.
2
Lithium concentrations in saliva, plasma and red blood cells of patients given lithium acetate.接受醋酸锂治疗的患者唾液、血浆和红细胞中的锂浓度。
Acta Psychiatr Scand. 1978 Jul;58(1):67-79. doi: 10.1111/j.1600-0447.1978.tb06922.x.
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Lithium transport in red cells of patients with affective disorders.
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The effect of concomitant use of neuroleptic drugs and lithium on the erythrocyte/plasma lithium ratio in Iranian patients with bipolar disorder.抗精神病药物与锂盐联合使用对伊朗双相情感障碍患者红细胞/血浆锂比值的影响。
J Clin Pharm Ther. 1996 Feb;21(1):3-7.
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[Distribution of lithium in the plasma and erythrocytes of frogs following a single injection of different doses of lithium carbonate].[单次注射不同剂量碳酸锂后青蛙血浆和红细胞中锂的分布]
Farmakol Toksikol. 1979 Jan-Feb;42(1):26-9.
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Clinical significance of sodium-dependent lithium transport in affective psychoses.
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The relationship of plasma to erythrocyte lithium levels in patients taking lithium carbonate.服用碳酸锂患者血浆与红细胞锂水平的关系。
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Evaluation of the lithium RBC/plasma ratio as a predictor of the prophylactic effect of lithium treatment in affective disorders.评估红细胞/血浆锂比值作为锂盐治疗情感障碍预防效果预测指标的价值。
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[The value of the measurement of intra-erythrocytic lithium in the bio-clinical surveillance of lithium therapy (author's transl)].红细胞内锂测量在锂治疗生物临床监测中的价值(作者译)
Ann Biol Clin (Paris). 1982;40(1):3-10.
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The red blood cell lithium/plasma lithium ratio. Significance in recurrent affective illness.
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引用本文的文献

1
Relevance of red blood cell Lithium concentration in the management of Lithium-treated bipolar and unipolar disorders: a systematic narrative review.红细胞锂浓度在锂盐治疗双相和单相情感障碍中的相关性:一项系统的叙述性综述
Int J Bipolar Disord. 2024 Oct 16;12(1):35. doi: 10.1186/s40345-024-00356-5.
2
Transmembrane distribution of lithium and sodium in erythrocytes of depressed patients.抑郁症患者红细胞中锂和钠的跨膜分布。
Psychopharmacology (Berl). 1980;68(3):249-55. doi: 10.1007/BF00428111.
3
Electrolyte metabolism in patients with periodic affective disorders during treatment with rubidium.
Psychopharmacology (Berl). 1983;81(4):301-9. doi: 10.1007/BF00427567.