Bonazzi del Poggetto C, Virtanen I, Lehto V P, Wahlström T, Saksela E
Int J Gynecol Pathol. 1983;1(4):359-66. doi: 10.1097/00004347-198301040-00006.
We studied the expression of cytoskeletal intermediate filaments in different types of ovarian and uterine sarcomas and carcinomas. In both uterine and ovarian leiomyosarcomas, in endometrial stromal sarcomas, and also in ovarian sarcomas, most tumor cells appeared to be positive for desmin, the muscle type of intermediate filament protein. In most of the tumors, vimentin was present only in some neoplastic cells and in the vascular endothelia. Interestingly, both uterine and ovarian malignant mixed mesodermal tumors appeared to express several types of intermediate filaments, most of the stromal cells being positive for vimentin or desmin, and the epithelial component expressing keratin. The results show that most of the sarcomatous tumors of the ovary and uterus express mainly muscle type of intermediate filament protein. The results also demonstrate the ability of cells of mesodermal origin to express epithelial cytoskeleton markers--cytokeratins.
我们研究了不同类型卵巢和子宫肉瘤及癌中细胞骨架中间丝的表达情况。在子宫和平滑肌肉瘤、子宫内膜间质肉瘤以及卵巢肉瘤中，大多数肿瘤细胞似乎对结蛋白呈阳性反应，结蛋白是中间丝蛋白的肌肉类型。在大多数肿瘤中，波形蛋白仅存在于一些肿瘤细胞和血管内皮细胞中。有趣的是，子宫和卵巢恶性混合性中胚叶肿瘤似乎表达几种类型的中间丝，大多数间质细胞对波形蛋白或结蛋白呈阳性，而上皮成分表达角蛋白。结果表明，卵巢和子宫的大多数肉瘤性肿瘤主要表达肌肉类型的中间丝蛋白。结果还证明了中胚层来源的细胞表达上皮细胞骨架标志物——细胞角蛋白的能力。
