Miettinen M, Lehto V P, Virtanen I
J Cutan Pathol. 1983 Jun;10(3):188-92. doi: 10.1111/j.1600-0560.1983.tb00325.x.
The cytoskeletal intermediate filaments of pigmented nevi and malignant melanomas (nine cases of each) were evaluated using monospecific antibodies against intermediate filament proteins and immunofluorescence microscopy. Both pigmented nevi and cutaneous malignant melanomas showed only vimentin-type intermediate filaments, but not keratin, neurofilaments, desmin or glial fibrillary acidic protein. Thus, nevi and melanomas do not show neural characteristics in the cytoskeletal intermediate filament pattern although they appear to show other neural markers. Vimentin - content in melanomas versus keratin - content in carcinomas may be used as a differential diagnostic feature.
运用针对中间丝蛋白的单特异性抗体及免疫荧光显微镜技术，对色素痣和恶性黑色素瘤（各9例）的细胞骨架中间丝进行了评估。色素痣和皮肤恶性黑色素瘤均仅显示波形蛋白型中间丝，而未显示角蛋白、神经丝、结蛋白或胶质纤维酸性蛋白。因此，尽管色素痣和黑色素瘤似乎显示出其他神经标志物，但在细胞骨架中间丝模式上并不表现出神经特征。黑色素瘤中的波形蛋白含量与癌中的角蛋白含量可作为鉴别诊断特征。
