Rengo F, Saccà L, Trimarco B, Violini R, Chiariello M, De Caprio L, Condorelli M
Pharmacology. 1978;16(1):2-10. doi: 10.1159/000136739.
This study was designed to investigate whether the cholinergic system is involved in the genesis of the reflex vasodilatation which follows the systemic hypertension induced by fast intravenous injection of norepinephrine in the dog. Accordingly, in 7 dogs the gracilis muscle was isolated and perfused and the reflex evoked. The analysis of the integrated areas of vasodilatation after atropine pretreatment showed a significant decrease of the reflex response in the perfused circulation. In fact, the mean value of the integrated areas of vasodilatation which was 66 +/- 8 mm Hg/min in the control condition, was reduced to 45 +/- 4 mm Hg/min after administration of atropine in the gracilis artery; meanwhile the integrated areas of systemic hypertension did not show any change. Phentolamine intra-arterial administration completely abolished the reflex. These results suggest the existence of a cholinergic component in the reflex vasodilatation induced by transitory baroreceptorial stimulation.
本研究旨在探讨胆碱能系统是否参与犬快速静脉注射去甲肾上腺素诱导的全身高血压后反射性血管舒张的发生机制。为此，对7只犬的股薄肌进行分离和灌注，并诱发反射。对阿托品预处理后血管舒张的积分面积分析表明，灌注循环中的反射反应显著降低。事实上，在对照条件下血管舒张积分面积的平均值为66±8 mmHg/min，在股薄肌动脉给予阿托品后降至45±4 mmHg/min；同时，全身高血压的积分面积未显示任何变化。动脉内给予酚妥拉明可完全消除该反射。这些结果提示，在短暂压力感受器刺激诱导的反射性血管舒张中存在胆碱能成分。
