胍乙啶对犬反射性血管舒张过程中组胺释放的影响。
Effects of guanethidine on histamine release during reflex vasodilatation in the dog.
作者信息
Condorelli M, Rasetti G, Rengo F, Ricciardelli B, Saccà L, Trimarco B, Volpe M
出版信息
Br J Pharmacol. 1977 Jul;60(3):379-84. doi: 10.1111/j.1476-5381.1977.tb07512.x.
1 The effects of guanethidine pretreatment on the release of [14C]-histamine during the reflex vasodilatation induced in the atropinized gracilis muscle by rapid intravenous administration of noradrenaline, were studied in dogs. 2 After guanethidine treatment the haemodynamic reflex response was completely abolished and no appreciable modification of [14C]-histamine release from the gracilis muscle following intravenous noradrenaline was observed. 3 These results suggest the hypothesis that the withdrawal of the sympathetic discharge represents the mechanism of histamine release during the reflex vasodilatation. Therefore, guanethidine would suppress both the passive and the histaminergic component of the baroreceptor reflex through the abolition of the sympathetic tone.
- 研究了胍乙啶预处理对狗在静脉快速注射去甲肾上腺素诱导的阿托品化股薄肌反射性血管舒张过程中[14C] - 组胺释放的影响。2. 胍乙啶处理后，血流动力学反射反应完全消失，静脉注射去甲肾上腺素后，未观察到股薄肌[14C] - 组胺释放有明显改变。3. 这些结果提示了一种假说，即交感神经放电的撤离是反射性血管舒张过程中组胺释放的机制。因此，胍乙啶通过消除交感神经张力，会抑制压力感受器反射的被动和组胺能成分。
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