[胆碱能系统在犬股薄肌反射性血管舒张发生中的作用（作者译）]

[The participation of the cholinergic system in the genesis of the reflex vasodilatation in the gracilis muscle of the dog (author's transl)].

作者信息

Rengo F, Perez G, Saccà L, Chiariello M, Trimarco B, De Caprio L, Condorelli M

出版信息

G Ital Cardiol. 1976;6(3):476-82.

Abstract

These experiments were undertaken to demonstrate the participation of the cholinergic system in the reflex vasodilatation in the gracilis muscle of the dog evoked by rapid i.v. injection of norepinephrine. The analysis of the integrated areas of vasodilatation curves after pretreatment with atropine showed a significant decrease of the reflex vasodilatation suggesting the participation of the cholinergic system to the mechanism underlying the phenomenon. The residue vasodilatation was completely abolished by the subsequent i.a. administration of phentolamine. On the other hand, guanethidine too could, also without pretreatment with atropine, nullify the reflex vasodilatation. This effect, therefore, does not permit the ruling out of the existence of a cholinergic component in the reflex vasodilatation since the actions of these drugs are not yet completely known.

摘要

进行这些实验是为了证明胆碱能系统在静脉快速注射去甲肾上腺素引起的犬股薄肌反射性血管舒张中的作用。用阿托品预处理后对血管舒张曲线积分面积的分析表明，反射性血管舒张显著降低，这表明胆碱能系统参与了该现象的潜在机制。随后动脉内注射酚妥拉明可完全消除残余的血管舒张。另一方面，胍乙啶在未经阿托品预处理的情况下也能消除反射性血管舒张。因此，由于这些药物的作用尚未完全明确，这种效应并不能排除反射性血管舒张中存在胆碱能成分。