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5-氮杂胞苷对小鼠Ki-BALB细胞系脑池内a颗粒的激活作用

Activation of intracisternal a particles by 5-azacytidine in mouse Ki-BALB cell line.

作者信息

Lasneret J, Canivet M, Hojman-Montes de Oca F, Tobaly J, Emanoil-Ravicovitch R, Peries J

出版信息

Virology. 1983 Jul 30;128(2):485-9. doi: 10.1016/0042-6822(83)90275-1.

DOI:10.1016/0042-6822(83)90275-1
PMID:6193633
Abstract

5-Azacytidine activates the production of intracisternal A particles (IAPs) in mouse Ki-BALB cell line as ascertained by electron microscopy scanning and numeration. Efficiency of the activation is higher than that obtained with iododeoxyuridine. The increase in particle production is concentration and time dependent. The results obtained in our system correlate the high IAP expression after drug treatment with a demethylation of IAP-related genes sequences.

摘要

通过电子显微镜扫描和计数确定，5-氮杂胞苷可激活小鼠Ki-BALB细胞系中核内A颗粒（IAPs）的产生。其激活效率高于用碘脱氧尿苷所获得的效率。颗粒产生的增加与浓度和时间相关。在我们的系统中所获得的结果将药物处理后IAP的高表达与IAP相关基因序列的去甲基化联系起来。

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