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地塞米松刺激小鼠（小家鼠）细胞中转座A型脑内池内类逆转录病毒基因的表达。

Dexamethasone stimulates expression of transposable type A intracisternal retroviruslike genes in mouse (Mus musculus) cells.

作者信息

Emanoil-Ravier R, Mercier G, Canivet M, Garcette M, Lasneret J, Peronnet F, Best-Belpomme M, Peries J

机构信息

Laboratoire de Virologie des Leucémies, LOI Centre National de la Recherche Scientifique, Hôpital Saint-Louis, Paris, France.

出版信息

J Virol. 1988 Oct;62(10):3867-9. doi: 10.1128/JVI.62.10.3867-3869.1988.

DOI:10.1128/JVI.62.10.3867-3869.1988
PMID:2843680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC253534/
Abstract

Dexamethasone treatment enhances expression of transposable intracisternal type A particles (IAP) at RNA and proteins levels in a murine retrovirus-transformed cell line (Ki-BALB). This effect was ascertained by electron microscopic numeration of IAP. By sequence comparison, we located glucocorticoid-responsive elements in IAP long terminal repeats. Their regulatory potential was tested on the promoter activity of an IAP long terminal repeat construct coupled with the chloramphenicol acetyltransferase gene. Our findings suggest that the IAP activation by dexamethasone occurs at the level of transcription.

摘要

地塞米松治疗可增强小鼠逆转录病毒转化细胞系（Ki-BALB）中A型顺式内粒状转座子（IAP）在RNA和蛋白质水平的表达。通过IAP的电子显微镜计数确定了这种效应。通过序列比较，我们在IAP长末端重复序列中定位了糖皮质激素反应元件。在与氯霉素乙酰转移酶基因偶联的IAP长末端重复序列构建体的启动子活性上测试了它们的调控潜力。我们的研究结果表明，地塞米松对IAP的激活发生在转录水平。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7140/253534/c4a95633d865/jvirol00089-0336-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7140/253534/3c848babeeeb/jvirol00089-0336-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7140/253534/c567f5ab5272/jvirol00089-0336-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7140/253534/c4a95633d865/jvirol00089-0336-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7140/253534/3c848babeeeb/jvirol00089-0336-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7140/253534/c567f5ab5272/jvirol00089-0336-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7140/253534/c4a95633d865/jvirol00089-0336-c.jpg

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Nucleic Acids Res. 1989 Nov 11;17(21):8631-44. doi: 10.1093/nar/17.21.8631.

本文引用的文献

1
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cells.在哺乳动物细胞中表达氯霉素乙酰转移酶的重组基因组。
Mol Cell Biol. 1982 Sep;2(9):1044-51. doi: 10.1128/mcb.2.9.1044-1051.1982.
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Intracisternal A particles: RNA expression and DNA methylation in murine teratocarcinoma cell lines.脑池内A颗粒：小鼠畸胎瘤细胞系中的RNA表达与DNA甲基化
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Intracisternal A-particle genes in Mus musculus: a conserved family of retrovirus-like elements.
小家鼠脑池内A颗粒基因：一个保守的类逆转录病毒元件家族。
Mol Cell Biol. 1981 Mar;1(3):216-27. doi: 10.1128/mcb.1.3.216-227.1981.
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Purification of mouse immunoglobulin heavy-chain messenger RNAs from total myeloma tumor RNA.从小鼠骨髓瘤肿瘤总RNA中纯化小鼠免疫球蛋白重链信使RNA。
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DNA rearrangement and altered RNA expression of the c-myb oncogene in mouse plasmacytoid lymphosarcomas.小鼠浆细胞样淋巴瘤中c-myb癌基因的DNA重排及RNA表达改变
Science. 1983 May 20;220(4599):795-8. doi: 10.1126/science.6687762.
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Expression and regulation of Escherichia coli lacZ gene fusions in mammalian cells.大肠杆菌lacZ基因融合体在哺乳动物细胞中的表达与调控
J Mol Appl Genet. 1983;2(1):101-9.
7
Mutant immunoglobulin genes have repetitive DNA elements inserted into their intervening sequences.突变的免疫球蛋白基因在其间隔序列中插入了重复的DNA元件。
Proc Natl Acad Sci U S A. 1982 Dec;79(23):7425-9. doi: 10.1073/pnas.79.23.7425.
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Sequence organization of cloned intracisternal A particle genes.克隆的脑内A粒子基因的序列组织
Cell. 1980 Sep;21(2):465-73. doi: 10.1016/0092-8674(80)90483-3.
9
Activation of intracisternal a particles by 5-azacytidine in mouse Ki-BALB cell line.5-氮杂胞苷对小鼠Ki-BALB细胞系脑池内a颗粒的激活作用
Virology. 1983 Jul 30;128(2):485-9. doi: 10.1016/0042-6822(83)90275-1.
10
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose.变性RNA与转移至硝酸纤维素膜上的小DNA片段的杂交。
Proc Natl Acad Sci U S A. 1980 Sep;77(9):5201-5. doi: 10.1073/pnas.77.9.5201.