Nosik N N, Balashov V I, Bukata L A, Fomina A N, Ershov F I
Vopr Virusol. 1980 Jul-Aug(4):473-7.
A method for aerosol use of interferon inducer in laboratory animals employing an ultrasonic aerosol generator is described. Formules and a table of calculations of an inhalation dose of interferon inducer in solution when atomized in a chamber, as well as in the use of individual masks for monkeys are presented. The aerosol administration of interferon inducer (replicative from RNA of phage f2) was found to be effective in inducing interferon production in mice and monkeys. Prophylactic administration of the inducer 4 and 24 hours before inoculation protected from 50% to 75% of mice against a fatal influenza infection.
描述了一种在实验动物中使用超声波气溶胶发生器进行干扰素诱导剂气溶胶给药的方法。给出了在室内雾化时溶液中干扰素诱导剂吸入剂量的配方和计算表，以及在猴子使用个体面罩时的情况。发现干扰素诱导剂（来自噬菌体f2的RNA复制型）的气溶胶给药在诱导小鼠和猴子产生干扰素方面是有效的。在接种前4小时和24小时预防性给予诱导剂可使50%至75%的小鼠免受致命性流感感染。
