Ford G P, Gopal T, Gaunt I F
Food Chem Toxicol. 1983 Aug;21(4):441-7. doi: 10.1016/0278-6915(83)90100-x.
Groups of 15 male and 15 female rats were given diets to provide intakes of 0 (control), 10, 40 or 160 mg 4-methyl-1-phenylpentan-2-ol/kg/day for 13 wk. No effects attributable to treatment were seen in the 10-mg/kg/day dose group. At 40 mg/kg/day the only finding was a decrease in serum glucose in males. This was of questionable toxicological significance. At 160 mg/kg/day a reduction in weight gain, probably due to unpalatability, a mild proteinuria in the females, an increased relative liver weight in males, increased caecal weights, a reduction in serum glucose and a lower reticulocyte count were recorded. No changes were observed in the histopathological examination. The no-untoward-effect level established in this study was 10 mg/kg/day.
将15只雄性和15只雌性大鼠分为几组，给予它们不同的饮食，以提供每天每千克体重0（对照）、10、40或160毫克的4-甲基-1-苯基戊-2-醇，持续13周。在每天10毫克/千克剂量组中未观察到与治疗相关的影响。在每天40毫克/千克时，唯一的发现是雄性大鼠血清葡萄糖降低。这一结果的毒理学意义存疑。在每天160毫克/千克时，记录到体重增加减少（可能是由于适口性差）、雌性大鼠出现轻度蛋白尿、雄性大鼠相对肝脏重量增加、盲肠重量增加、血清葡萄糖降低以及网织红细胞计数降低。组织病理学检查未观察到变化。本研究确定的无不良影响水平为每天10毫克/千克。
