Fisher N, Berry R, Hardy J
Food Chem Toxicol. 1983 Aug;21(4):423-6. doi: 10.1016/0278-6915(83)90097-2.
Male and female Wistar rats were fed for 28 days on a diet containing either chlorinated (1257 or 2506 ppm chlorine) or unchlorinated flour. No significant differences between groups in body weight were observed in the males. A significant inverse correlation between body weight and treatment level, attributable to a corresponding trend in food intakes, was found for the females only. No significant differences between absolute organ weights were found, but when the weights were adjusted for covariance with body weight, dose-related increases in kidney weight (males) and liver weight (both sexes) were found. Histopathological examination revealed no pathological tissue changes attributable to the chlorination of the flour.
将雄性和雌性Wistar大鼠用含有氯化（1257或2506 ppm氯）或未氯化面粉的饮食喂养28天。在雄性大鼠中，各实验组之间的体重未观察到显著差异。仅在雌性大鼠中发现体重与处理水平之间存在显著负相关，这归因于食物摄入量的相应趋势。绝对器官重量之间未发现显著差异，但当对体重协变量进行调整后，发现雄性大鼠的肾脏重量和两性的肝脏重量均有与剂量相关的增加。组织病理学检查未发现面粉氯化导致的病理组织变化。
