蛇咬伤受害者血清和尿液中的蛋白酶抑制剂。

Protease inhibitors in serum and urine of snakebite victims.

作者信息

Bhat A R, Rau N R, Pattabiraman T N

出版信息

Biochem Med. 1983 Aug;30(1):1-7. doi: 10.1016/0006-2944(83)90002-9.

PMID:6194792

Abstract

In victims of poisonous snakebites, serum total antichymotryptic activity but not the antitryptic activity was found to be increased. In addition, urinary antitryptic activity was found to be markedly elevated. In nonpoisonous snakebite cases, no such differences were noted. Ion-exchange chromatographic analysis of serum protease inhibitors revealed the absence of inhibitory activity in the alpha 2-macroglobulin fraction and elevation of alpha 1-antichymotrypsin in poisonous bite cases. In addition, there was a significant increase in the ratio of cationic to anionic fraction of alpha 1-protease inhibitor compared to normals. Urinary antitryptic activity could serve as a reliable index in assessing clinical improvement in snakebite victims during treatment and in differentiating poisonous from nonpoisonous cases.

摘要

在毒蛇咬伤患者中，发现血清总抗糜蛋白酶活性升高，但抗胰蛋白酶活性未升高。此外，还发现尿抗胰蛋白酶活性显著升高。在无毒蛇咬伤病例中，未观察到此类差异。血清蛋白酶抑制剂的离子交换色谱分析显示，在毒蛇咬伤病例中，α2-巨球蛋白组分缺乏抑制活性，而α1-抗糜蛋白酶升高。此外，与正常人相比，α1-蛋白酶抑制剂的阳离子部分与阴离子部分的比例显著增加。尿抗胰蛋白酶活性可作为评估蛇咬伤患者治疗期间临床改善情况以及区分毒蛇咬伤与无毒蛇咬伤病例的可靠指标。