[Thromboxane, beta-thromboglobulin and the degree of blood sugar control in type 1 diabetes mellitus].

Plasma concentrations of beta-thromboglobulin (B-TG) and of Thromboxane B2 (TxB2) were found to be increased in diabetics but their values didn't result in relation to simultaneous fasting glycemia. The aim of this study was to elucidate if the B-TG and TxB2 levels were correlated with the indexes of medium and long-term diabetes control, namely non-enzymatic glycosylation of serum proteins (GSP) and irreversibly glycosylated hemoglobin, stable (S) HbA1. Therefore the behaviour of B-TG, TxB2, glycemia, GSP, T-HbA1 (stable and labile) and S-HbA1 were determined in 37 type 1 diabetics without any apparent vascular complication. All these parameters, except S-HbA1, were studied also in 8 ketoacidotic diabetic out patients before and during the recovery of metabolic control. Glycemia was assayed by the method of Trinder; B-TG and TxB2 were determined by radio-immunoassay. GSP was measured by chemical procedure using thiobarbituric acid (TBA test). The concentration of HbA1 was performed before and after incubation of erythrocytes for 6 h at 37 degrees C in saline to evaluate T and S-HbA1. In the out-patients B-TG and TxB2 were found to be correlated only with GSP. During the recovery of glycemic control a progressive decrease in the levels of T-BG and TxB2 was observed. We conclude that in vitro platelet activation i.e. B-TG and TxB2 levels, stable metabolite of proaggregatory TxA2, are deranged in relation to medium term glycemic disturbance rather than to short-term glucose fluctuations.