Tisdale M J
Exp Cell Biol. 1983;51(5):250-6. doi: 10.1159/000163200.
Prostaglandins are secreted by a variety of animal and human tumours. A higher prostaglandin production is sometimes associated with a decreased tendency to metastasis, though there are features of the metastatic cascade where prostaglandins might be expected to facilitate dissemination. Prostaglandins may aid metastases through the mediation of proteolytic enzyme production, by prostaglandin-induced neovascularization or by subversion of the immune response. Inhibitors of platelet aggregation such as prostacyclin on thromboxane A2 synthetase inhibitors may be useful in the prevention of metastatic spread of cancer.
前列腺素由多种动物和人类肿瘤分泌。虽然在转移级联反应的某些特征中，前列腺素可能会促进扩散，但有时前列腺素产生量较高与转移倾向降低有关。前列腺素可能通过介导蛋白水解酶的产生、前列腺素诱导的新血管形成或颠覆免疫反应来促进转移。血小板聚集抑制剂，如前列环素或血栓素A2合成酶抑制剂，可能有助于预防癌症的转移扩散。
