Kort W J, Hulsman L O, van Schalkwijk W P, Weijma I M, Zondervan P E, Westbroek D L
J Natl Cancer Inst. 1986 Apr;76(4):711-20. doi: 10.1093/jnci/76.4.711.
For suppression of primary tumor growth and metastatic spread, aspirin and theophylline, either alone or combined, were given daily to inbred female BN rats after sc implantation of a syngeneic nonimmunogenic tumor. Treatment with 200 mg aspirin/kg (body wt) resulted in a statistically significant regression of tumor growth as well as of the number of metastases in the lungs. Aspirin given in a lower dose (20 mg/kg) did not show significant difference from the vehicle group. Theophylline (75 mg/kg) significantly increased primary tumor growth as well as lung metastases. Inhibition of in vitro platelet aggregation, determined in whole blood taken from non-tumor-bearing animals treated with the same therapeutic regimen, was most pronounced in those groups in which tumor growth and spread were significantly retarded. However, this positive correlation between inhibition of tumor spread and platelet aggregation was not associated with a favorable balance of prostacyclin and thromboxane A2 in these animals.
为抑制原发性肿瘤生长和转移扩散，在近交系雌性BN大鼠皮下植入同基因非免疫原性肿瘤后，每日单独或联合给予阿司匹林和茶碱。给予200 mg阿司匹林/ kg（体重）治疗导致肿瘤生长以及肺转移数量出现统计学上的显著消退。较低剂量（20 mg / kg）的阿司匹林与赋形剂组相比未显示出显著差异。茶碱（75 mg / kg）显著增加了原发性肿瘤生长以及肺转移。在用相同治疗方案处理的无肿瘤动物所采集的全血中测定的体外血小板聚集抑制，在肿瘤生长和扩散显著延迟的那些组中最为明显。然而，肿瘤扩散抑制与血小板聚集之间的这种正相关与这些动物中前列环素和血栓素A2的良好平衡无关。
