Franzin G, Zamboni G, Dina R, Scarpa A, Fratton A
Histopathology. 1983 Sep;7(5):719-28. doi: 10.1111/j.1365-2559.1983.tb02284.x.
A light microscopy and histochemical study of 24 juvenile and 27 inflammatory polyps showed that both may derive from inflammatory processes. Granulation tissue, secondary to spontaneous local inflammation or due to surgical procedures may subsequently be covered by regenerating epithelium which lines haemorrhagic cavities and mucus lakes to form irregular, elongated and cystic glands, which are characteristic of juvenile polyps. Both juvenile and inflammatory polyps showed cystic, metaplastic and 'transitional-type' glands. The mucin distribution was identical in both types of polyps. All these findings suggest a common origin of the polyps. The presence of 'transitional-type' glands seems to confirm these as a secondary regenerative phenomenon rather than pre-neoplastic, although dysplastic changes in juvenile polyps have been described. It is suggested that both the juvenile and inflammatory polyps may undergo dysplasia only in genetically predisposed subjects. However, this event seems to be very rare.
对24个幼年性息肉和27个炎性息肉进行的光学显微镜和组织化学研究表明，两者可能都源于炎症过程。继发于自发性局部炎症或手术操作的肉芽组织随后可能被再生上皮覆盖，该上皮衬于出血腔和黏液湖，形成不规则、细长的囊性腺体，这是幼年性息肉的特征。幼年性息肉和炎性息肉均显示出囊性、化生和“过渡型”腺体。两种类型息肉中的黏蛋白分布相同。所有这些发现提示息肉有共同的起源。“过渡型”腺体的存在似乎证实其为继发性再生现象而非肿瘤前病变，尽管已有关于幼年性息肉发育异常改变的描述。有人提出，幼年性息肉和炎性息肉可能仅在有遗传易感性的个体中发生发育异常。然而，这种情况似乎非常罕见。
