Seibel H R, Dolwick M F, Bush F M, Craig S S
Acta Anat (Basel). 1978;100(3):354-64. doi: 10.1159/000144916.
The ultrastructure of rat masseter muscle was examined at 15 min, 1 and 6 h, and 1 and 2 days following a single injection of 2% lidocaine. Lesions developed within 15 min. The plasma membrane was disrupted and invaginated. The nuclei were pyknotic and the mitochondria appeared swollen. The myofibrils separated and became disoriented. By 1 and 6 h, these changes were severe. By 1 day, the macrophages appeared in damaged myofibers. The presence of a few presumptive myoblasts signaled the onset of regeneration. By 2 days, presumptive myoblasts formed within the basement membrane. The basal lamina proved most resistant to injury. Regeneration of masseter muscle following the damage produced by lidocaine appeared discontinuous in nature. The singly nucleated presumptive myoblasts seemed to arise within the lesions.
在单次注射2%利多卡因后的15分钟、1小时、6小时以及1天和2天，对大鼠咬肌的超微结构进行了检查。损伤在15分钟内就出现了。质膜被破坏并内陷。细胞核固缩，线粒体出现肿胀。肌原纤维分离并变得排列紊乱。到1小时和6小时时，这些变化很严重。到1天时，巨噬细胞出现在受损的肌纤维中。一些推定的成肌细胞的出现标志着再生的开始。到2天时，推定的成肌细胞在基底膜内形成。基膜被证明对损伤最具抵抗力。利多卡因造成损伤后咬肌的再生在本质上似乎是不连续的。单核的推定成肌细胞似乎在损伤部位出现。
