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肌肉注射药物引起的肌纤维坏死。

Muscle fibre necrosis induced by intramuscular injection of drugs.

作者信息

Manor D, Sadeh M

机构信息

Department of Neurology, Chaim Sheba Medical Center, Tel Hashomer, Israel.

出版信息

Br J Exp Pathol. 1989 Aug;70(4):457-62.

PMID:2765397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2040563/
Abstract

A number of amphiphilic and lipid-soluble drugs of heterogeneous pharmacological properties, when injected into rat anterior tibial muscles, induced acute muscle fibre necrosis. The myotoxic agents were: penicillin, cloxacillin, phenobarbital, haloperidol, diazepam, hydantoin, metoclopramide, pentazocine and chlorpromazine. The regenerative process, studied using the latter three medications, showed rapid regeneration, complete within 3 weeks. Injection of the water-soluble drugs aminophylline, tranexamic acid and vitamins B6 and B12 produced no tissue damage. The pathogenesis of muscle fibre necrosis is suggested to involve direct damage to cell membranes by lipid soluble drugs.

摘要

许多具有不同药理特性的两亲性和脂溶性药物，注射到大鼠胫前肌后，会引发急性肌纤维坏死。这些肌毒性药物包括：青霉素、氯唑西林、苯巴比妥、氟哌啶醇、地西泮、乙内酰脲、甲氧氯普胺、喷他佐辛和氯丙嗪。使用后三种药物进行研究的再生过程显示再生迅速，在3周内完成。注射水溶性药物氨茶碱、氨甲环酸以及维生素B6和B12未造成组织损伤。肌纤维坏死的发病机制被认为涉及脂溶性药物对细胞膜的直接损伤。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/e22d2574abb4/brjexppathol00148-0067-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/0963c133ac96/brjexppathol00148-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/cf8b648edfe2/brjexppathol00148-0066-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/be69506798d1/brjexppathol00148-0066-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/fc33b9327d02/brjexppathol00148-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/209397cbc128/brjexppathol00148-0067-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/e22d2574abb4/brjexppathol00148-0067-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/0963c133ac96/brjexppathol00148-0066-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/cf8b648edfe2/brjexppathol00148-0066-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/be69506798d1/brjexppathol00148-0066-c.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/fc33b9327d02/brjexppathol00148-0067-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/209397cbc128/brjexppathol00148-0067-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2f26/2040563/e22d2574abb4/brjexppathol00148-0067-c.jpg

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本文引用的文献

1
Pharmacologic correlation between local anesthetic-induced myotoxicity and disturbances of intracellular calcium distribution.局部麻醉药诱导的肌毒性与细胞内钙分布紊乱之间的药理学关联。
Toxicol Appl Pharmacol. 1980 Feb;52(2):187-98. doi: 10.1016/0041-008x(80)90105-2.
2
Protein synthesis in bupivacaine (marcaine)-treated, regenerating skeletal muscle.
Muscle Nerve. 1982 Apr;5(4):281-90. doi: 10.1002/mus.880050404.
3
Intramuscular injections in children.
Pediatrics. 1982 Dec;70(6):944-8.
4
全膝关节置换术中关节周围与关节内注射氨甲环酸的疗效及全身吸收情况：一项前瞻性随机对照试验
Arthroplast Today. 2021 Aug 7;11:1-5. doi: 10.1016/j.artd.2021.06.005. eCollection 2021 Oct.
4
Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration.肌纤维坏死促进肌肉干细胞增殖，通过在再生过程中释放 Tenascin-C。
Cell Res. 2020 Dec;30(12):1063-1077. doi: 10.1038/s41422-020-00393-6. Epub 2020 Aug 24.
5
A Nitric Oxide-Donating Statin Decreases Portal Pressure with a Better Toxicity Profile than Conventional Statins in Cirrhotic Rats.一种具有供氮作用的他汀类药物可降低肝硬化大鼠的门静脉压力，其毒性特征优于传统他汀类药物。
Sci Rep. 2017 Jan 13;7:40461. doi: 10.1038/srep40461.
6
Peri-articular tranexamic acid injection in total knee arthroplasty: a randomized controlled trial.全膝关节置换术中关节周围注射氨甲环酸：一项随机对照试验
BMC Musculoskelet Disord. 2016 Jul 26;17:313. doi: 10.1186/s12891-016-1176-7.
7
Proliferative and non-proliferative lesions of the rat and mouse soft tissue, skeletal muscle and mesothelium.大鼠和小鼠软组织、骨骼肌及间皮的增殖性和非增殖性病变
J Toxicol Pathol. 2013;26(3 Suppl):1S-26S. doi: 10.1293/tox.26.1S.
8
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Acta Neuropathol. 1995;90(3):299-304. doi: 10.1007/BF00296514.
Differential reactivities of fucosyl GM1 and GM1 gangliosides on rat erythrocyte membrane revealed by analysis with anti-fucosyl GM1 and GM1 antisera.抗岩藻糖基GM1和GM1抗血清分析揭示大鼠红细胞膜上岩藻糖基GM1和GM1神经节苷脂的差异反应性。
J Biochem. 1983 Jul;94(1):1-10. doi: 10.1093/oxfordjournals.jbchem.a134316.
5
Pentazocine abuse masquerading as familial myopathy.以家族性肌病伪装的喷他佐辛滥用
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6
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7
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8
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9
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