Pregnancy as a trigger of epidermolysis bullosa acquisita.

A 38-year-old woman developed epidermolysis bullosa acquisita (A-EBD) in connection with her third pregnancy. The activity of visible blistering disappeared at menopause. Direct immunofluorescence examination showed linear deposition of IgG and C'3 in the basement membrane zone. The light and electron microscopical findings of the disease were consistent with A-EBD. We assume that the bullous scarring eruption was triggered by a hormonal mechanism.