Dahlin K J, Chan A C, Benson E S, Hegarty P V
Am J Clin Nutr. 1978 Jan;31(1):94-9. doi: 10.1093/ajcn/31.1.94.
Ultrastructural repair of the morphological damages produced in nutritional muscular dystrophy was studied by refeeding dystrophic rabbits with vitamin E. Weanling (1.2 kg body weight) rabbits were fed a vitamin E-deficient diet for 24 days. Half of this group was then sacrificed and the remainder was given an initial oral dose of 50 mg of DL-alpha-tocopherol acetate and a vitamin E supplemented diet for 28 days. Control animals were fed a vitamin E supplemented diet with 50 mg of DL-alpha-tocopherol acetate per kilogram of diet. Abnormalities of dystrophic muscles included streaming Z-disk, degenerated mitochondria, fragmented sacroplasmic reticulum and development and aggregation of myelin figures. The effect of vitamin E therapy resulted in significant repair of the dystrophic muscle. Small localized sections of rehabilitated muscle revealed abnormal mitochondria and residual myelin figures.
通过用维生素E重新喂养营养不良性肌病的兔子，研究了营养性肌营养不良所产生的形态学损伤的超微结构修复情况。断奶（体重1.2千克）兔子被喂以维生素E缺乏的饮食24天。然后将该组中的一半兔子处死，其余兔子给予50毫克DL-α-生育酚醋酸酯的初始口服剂量，并给予补充维生素E的饮食28天。对照动物被喂以每千克饮食含50毫克DL-α-生育酚醋酸酯的补充维生素E的饮食。营养不良性肌肉的异常包括Z盘流注、线粒体退化、肌浆网断裂以及髓鞘样结构的形成和聚集。维生素E治疗的效果导致营养不良性肌肉有显著修复。修复后肌肉的小局部区域显示出线粒体异常和残留的髓鞘样结构。
