Prieto-Gomez B, Reyes-Vazquez C, Dafny N
J Neurosci Res. 1983;10(3):273-8. doi: 10.1002/jnr.490100305.
Three incremental doses of recombinant alpha-interferon (IF) were applied iontophoretically to hippocampal and hypothalamic cells. IF produced a dose-dependent long-lasting excitation in hippocampal neurons, whereas, in the hypothalamus alpha-IF elicited biphasic responses. The highest IF currents induced changes in the amplitude of the action potentials on both structures. Our observations suggest that IF could have a selective effect on the specific areas studied.
将三剂递增剂量的重组α干扰素（IF）通过离子电渗法施加于海马体和下丘脑细胞。IF在海马体神经元中产生剂量依赖性的持久兴奋，而在下丘脑中，α-IF引发双相反应。最高的IF电流引起了这两个结构上动作电位幅度的变化。我们的观察结果表明，IF可能对所研究的特定区域具有选择性作用。
