干扰素对腹内侧下丘脑和背侧海马体的不同作用。
Differential effects of interferon on ventromedial hypothalamus and dorsal hippocampus.
作者信息
Prieto-Gomez B, Reyes-Vazquez C, Dafny N
出版信息
J Neurosci Res. 1983;10(3):273-8. doi: 10.1002/jnr.490100305.
PMID:6196489
Abstract
Three incremental doses of recombinant alpha-interferon (IF) were applied iontophoretically to hippocampal and hypothalamic cells. IF produced a dose-dependent long-lasting excitation in hippocampal neurons, whereas, in the hypothalamus alpha-IF elicited biphasic responses. The highest IF currents induced changes in the amplitude of the action potentials on both structures. Our observations suggest that IF could have a selective effect on the specific areas studied.
摘要
将三剂递增剂量的重组α干扰素（IF）通过离子电渗法施加于海马体和下丘脑细胞。IF在海马体神经元中产生剂量依赖性的持久兴奋，而在下丘脑中，α-IF引发双相反应。最高的IF电流引起了这两个结构上动作电位幅度的变化。我们的观察结果表明，IF可能对所研究的特定区域具有选择性作用。
相似文献
1
Differential effects of interferon on ventromedial hypothalamus and dorsal hippocampus.干扰素对腹内侧下丘脑和背侧海马体的不同作用。
J Neurosci Res. 1983;10(3):273-8. doi: 10.1002/jnr.490100305.
2
Effects of morphine on sensory-evoked responses recorded from central gray, reticular formation, thalamus, hypothalamus, limbic system, basal ganglia, dorsal raphe, locus ceruleus, and pineal body.吗啡对从中央灰质、网状结构、丘脑、下丘脑、边缘系统、基底神经节、中缝背核、蓝斑核和松果体记录的感觉诱发反应的影响。
J Neurosci Res. 1980;5(5):399-412. doi: 10.1002/jnr.490050505.
3
[Effect of cholecystokinin and bombesin on the neuronal impulse activity of the ventromedial hypothalamic nucleus].[胆囊收缩素和蛙皮素对下丘脑腹内侧核神经元冲动活动的影响]
Fiziol Zh SSSR Im I M Sechenova. 1987 Dec;73(12):1615-9.
4
Excitation of hippocampal neurones by posterior pituitary peptides: vasopressin and oxytocin compared.
Prog Brain Res. 1983;60:147-51. doi: 10.1016/S0079-6123(08)64382-4.
5
Dose effects of morphine on the spontaneous unit activity recorded from the thalamus, hypothalamus, septum, hippocampus, reticular formation, central gray, and caudate nucleus.
J Neurosci Res. 1983;9(2):115-26. doi: 10.1002/jnr.490090203.
6
Naloxone antagonizes behavioural and ECoG effects induced by systemic or intracerebral administration of some lymphokines.纳洛酮可拮抗全身或脑内给予某些淋巴因子所诱导的行为和脑电图效应。
Ann Ist Super Sanita. 1990;26(1):99-106.
7
Obesity induced by kainic acid microlesion in the ventromedial hypothalamus in rats.海人酸微损伤大鼠腹内侧下丘脑诱导的肥胖。
Acta Physiol Hung. 1986;68(1):5-9.
8
[Effect of glucose on the polysensory properties of neurons of the ventromedial nucleus of the hypothalamus].[葡萄糖对下丘脑腹内侧核神经元多感觉特性的影响]
Fiziol Zh SSSR Im I M Sechenova. 1988 Mar;74(3):318-25.
9
Effects of trifluoperazine on synaptically evoked potentials and membrane properties of CA1 pyramidal neurons of rat hippocampus in situ and in vitro.三氟拉嗪对大鼠海马CA1锥体神经元在体和离体情况下突触诱发电位及膜特性的影响。
Synapse. 1993 Jan;13(1):10-9. doi: 10.1002/syn.890130103.
10
Effects of monomethylarsonic and monomethylarsonous acid on evoked synaptic potentials in hippocampal slices of adult and young rats.一甲基胂酸和一甲基亚胂酸对成年和幼年大鼠海马脑片诱发突触电位的影响。
Toxicol Appl Pharmacol. 2009 Apr 1;236(1):115-23. doi: 10.1016/j.taap.2008.12.025. Epub 2009 Jan 20.
Zotero 插件