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多发性硬化症中的脑脊液和血清干扰素：纵向研究

CSF and serum interferon in multiple sclerosis: longitudinal study.

作者信息

Salonen R

出版信息

Neurology. 1983 Dec;33(12):1604-6. doi: 10.1212/wnl.33.12.1604.

DOI:10.1212/wnl.33.12.1604
PMID:6196687
Abstract

We studied interferon (IFN) in the serum and CSF of 31 patients with multiple sclerosis. The sensitive IFN bioassay required only small volumes and detected IFN levels as low as 0.5 international units/ml (CSF) or 4 international units/ml (serum) of IFN. Two hundred twenty-eight paired CSF/serum samples were tested, and no IFN was found.

摘要

我们研究了31例多发性硬化症患者血清和脑脊液中的干扰素（IFN）。灵敏的IFN生物测定法仅需少量样本，并能检测低至0.5国际单位/毫升（脑脊液）或4国际单位/毫升（血清）的IFN水平。我们检测了228对脑脊液/血清样本，未发现IFN。

相似文献

1
CSF and serum interferon in multiple sclerosis: longitudinal study.多发性硬化症中的脑脊液和血清干扰素：纵向研究
Neurology. 1983 Dec;33(12):1604-6. doi: 10.1212/wnl.33.12.1604.
2
Intermittent interferonemia and interferon responses in multiple sclerosis.多发性硬化症中的间歇性干扰素血症和干扰素反应。
Clin Immunol Immunopathol. 1991 Jan;58(1):18-32. doi: 10.1016/0090-1229(91)90145-z.
3
Interferon in the serum and cerebrospinal fluid in patients with multiple sclerosis and other neurological disorders.多发性硬化症及其他神经系统疾病患者血清和脑脊液中的干扰素。
Acta Neurol Scand. 1976 Feb;53(2):152-60. doi: 10.1111/j.1600-0404.1976.tb04333.x.
4
[Interferon production in multiple sclerosis].
Vopr Virusol. 1981 Mar-Apr(2):218-21.
5
Immune Parameters That Distinguish Multiple Sclerosis Patients from Patients with Other Neurological Disorders at Presentation.初诊时区分多发性硬化症患者与其他神经系统疾病患者的免疫参数。
PLoS One. 2015 Aug 28;10(8):e0135434. doi: 10.1371/journal.pone.0135434. eCollection 2015.
6
[Measurement of gamma-interferon in sera and CSF in patients with multiple sclerosis and inflammatory neurological diseases].[多发性硬化症和炎症性神经疾病患者血清和脑脊液中γ-干扰素的测量]
Rinsho Shinkeigaku. 1990 May;30(5):557-9.
7
Assay of interferon and viral antibodies in the cerebrospinal fluid in clinical neurology and psychiatry.临床神经学与精神病学中脑脊液干扰素和病毒抗体的检测
Acta Biol Med Ger. 1979;38(5-6):879-93.
8
Multiple sclerosis is associated with an imbalance between tumour necrosis factor-alpha (TNF-alpha)- and IL-10-secreting blood cells that is corrected by interferon-beta (IFN-beta) treatment.多发性硬化症与肿瘤坏死因子-α（TNF-α）分泌血细胞和白细胞介素-10分泌血细胞之间的失衡有关，而干扰素-β（IFN-β）治疗可纠正这种失衡。
Clin Exp Immunol. 2000 Apr;120(1):147-53. doi: 10.1046/j.1365-2249.2000.01175.x.
9
Serum interferon in patients with psychosis.
Am J Psychiatry. 1985 Oct;142(10):1184-6. doi: 10.1176/ajp.142.10.1184.
10
[Circulating serum interferon and its effect on human natural killer cell activity].[循环血清干扰素及其对人自然杀伤细胞活性的影响]
Biull Eksp Biol Med. 1994 Dec;118(12):619-22.

引用本文的文献

1
Regional hypomyelination and dysplasia in transgenic mice with astrocyte-directed expression of interferon-gamma.星形胶质细胞定向表达干扰素-γ的转基因小鼠中的局部髓鞘形成不足和发育异常
J Mol Neurosci. 2000 Aug;15(1):45-59. doi: 10.1385/JMN:15:1:45.
2
Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis.γ-干扰素诱导的少突胶质细胞死亡：对多发性硬化症发病机制的影响。
Mol Med. 1995 Nov;1(7):732-43.
3
Absence of immunoreactive interferon-alpha in CSF from patients with multiple sclerosis.多发性硬化症患者脑脊液中无免疫反应性α干扰素。
J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):102-3. doi: 10.1136/jnnp.49.1.102.
4
Clinical pharmacokinetics of interferons.干扰素的临床药代动力学
Clin Pharmacokinet. 1990 Nov;19(5):390-9. doi: 10.2165/00003088-199019050-00003.
5
Interferons in multiple sclerosis. A review of the evidence.干扰素与多发性硬化症。证据综述。
Drugs. 1992 Dec;44(6):946-62. doi: 10.2165/00003495-199244060-00004.