• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

反对血管活性肠肽（VIP）作为气道神经源性反应中的扩张剂以及支持P物质作为收缩剂的证据。

Evidence against vasoactive intestinal polypeptide (VIP) as a dilator and in favour of substance P as a constrictor in airway neurogenic responses.

作者信息

Karlsson J A, Persson C G

出版信息

Br J Pharmacol. 1983 Jul;79(3):634-6. doi: 10.1111/j.1476-5381.1983.tb09999.x.

DOI:10.1111/j.1476-5381.1983.tb09999.x
PMID:6197124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2044903/
Abstract

Propranolol-resistant neurogenic relaxation persisted in (carbachol-contracted) guinea-pig tracheae already relaxed by supramaximal concentrations of vasoactive intestinal polypeptide (VIP). Also, VIP relaxed preparations that were under neurogenic inhibition. In hilus bronchi, about 60% of a neurogenic contraction was atropine-resistant. (Arg5, D-Trp7.9) SP 5-11 specifically antagonized this contraction and those produced by exogenous substance P. Substance P, but not VIP, seems to be involved in nerve-mediated effects on guinea-pig airway tone.

摘要

在已被超最大浓度的血管活性肠肽（VIP）松弛的（卡巴胆碱收缩的）豚鼠气管中，普萘洛尔耐药性神经源性松弛持续存在。此外，VIP使处于神经源性抑制状态的标本松弛。在肺门支气管中，约60%的神经源性收缩对阿托品耐药。（Arg5，D-Trp7.9）SP 5-11特异性拮抗这种收缩以及由外源性P物质产生的收缩。P物质而非VIP似乎参与了对豚鼠气道张力的神经介导作用。

相似文献

1
Evidence against vasoactive intestinal polypeptide (VIP) as a dilator and in favour of substance P as a constrictor in airway neurogenic responses.反对血管活性肠肽（VIP）作为气道神经源性反应中的扩张剂以及支持P物质作为收缩剂的证据。
Br J Pharmacol. 1983 Jul;79(3):634-6. doi: 10.1111/j.1476-5381.1983.tb09999.x.
2
Relaxation of isolated guinea pig trachea, bronchi and pulmonary arteries produced by vasoactive intestinal peptide (VIP).血管活性肠肽（VIP）对豚鼠离体气管、支气管及肺动脉的舒张作用。
Eur J Pharmacol. 1984 Feb 17;98(2):279-84. doi: 10.1016/0014-2999(84)90602-2.
3
Vasoactive intestinal polypeptide induces neurogenic contraction of guinea-pig ileum. Involvement of acetylcholine and substance P.
Regul Pept. 1992 Mar 19;38(2):155-64. doi: 10.1016/0167-0115(92)90054-x.
4
Neither vasoactive intestinal peptide (VIP) nor purine derivatives may mediate non-adrenergic tracheal inhibition.血管活性肠肽（VIP）和嘌呤衍生物都不能介导非肾上腺素能性气管抑制。
Acta Physiol Scand. 1984 Dec;122(4):589-98. doi: 10.1111/j.1748-1716.1984.tb07548.x.
5
Effects of epithelium removal on relaxation of airway smooth muscle induced by vasoactive intestinal peptide and electrical field stimulation.上皮去除对血管活性肠肽和电场刺激诱导的气道平滑肌舒张的影响。
Br J Pharmacol. 1990 May;100(1):73-8. doi: 10.1111/j.1476-5381.1990.tb12054.x.
6
Pharmacological characterization of the autonomous innervation of the guinea pig tracheobronchial smooth muscle.豚鼠气管支气管平滑肌自主神经支配的药理学特性
Acta Pharmacol Toxicol (Copenh). 1981 Aug;49(2):150-7. doi: 10.1111/j.1600-0773.1981.tb00884.x.
7
Enzymatic modulation of vasoactive intestinal peptide and nonadrenergic noncholinergic inhibitory responses in guinea pig tracheae.豚鼠气管中血管活性肠肽的酶促调节及非肾上腺素能非胆碱能抑制反应
Am Rev Respir Dis. 1990 Nov;142(5):1119-23. doi: 10.1164/ajrccm/142.5.1119.
8
Different effects of substance P and vasoactive intestinal peptide on the motor function of bovine intraocular muscles.
Invest Ophthalmol Vis Sci. 1983 Dec;24(12):1566-71.
9
Non-cholinergic neurotransmission and the effects of peptides on the urinary bladder of guinea-pigs and rabbits.非胆碱能神经传递以及肽类对豚鼠和家兔膀胱的影响。
J Physiol. 1986 May;374:103-15. doi: 10.1113/jphysiol.1986.sp016068.
10
Evidence against VIP-involvement in neurogenic relaxations of the mouse anococcygeus muscle.反对血管活性肠肽参与小鼠肛门尾骨肌神经源性舒张的证据。
J Pharm Pharmacol. 1986 Oct;38(10):767-9. doi: 10.1111/j.2042-7158.1986.tb04488.x.

引用本文的文献

1
A role for capsaicin sensitive, tachykinin containing nerves in chronic coughing and sneezing but not in asthma: a hypothesis.辣椒素敏感的、含速激肽的神经在慢性咳嗽和打喷嚏中起作用，但在哮喘中不起作用：一种假说。
Thorax. 1993 Apr;48(4):396-400. doi: 10.1136/thx.48.4.396.
2
Relaxation of cat tracheobronchial and pulmonary arterial smooth muscle by vasoactive intestinal peptide: lack of influence by peptidase inhibitors.血管活性肠肽对猫气管支气管和肺动脉平滑肌的舒张作用：肽酶抑制剂无影响。
Br J Pharmacol. 1984 Jun;82(2):321-8. doi: 10.1111/j.1476-5381.1984.tb10766.x.
3
Involvement of capsaicin-sensitive afferent neurones in a vagal-dependent interaction between leukotriene D4 and histamine on bronchomotor tone.辣椒素敏感传入神经元参与白三烯D4与组胺之间基于迷走神经的支气管运动张力相互作用。
Agents Actions. 1984 Dec;15(5-6):500-8. doi: 10.1007/BF01966763.
4
Possible role of calcium in neurotransmission to the lower airways.钙在向气道下部的神经传递中的可能作用。
Br J Clin Pharmacol. 1985;20 Suppl 2(Suppl 2):281S-287S. doi: 10.1111/j.1365-2125.1985.tb02814.x.
5
The effects of vasoactive intestinal peptide (VIP) antagonists, and VIP and peptide histidine isoleucine antisera on non-adrenergic, non-cholinergic relaxations of tracheal smooth muscle.血管活性肠肽（VIP）拮抗剂、VIP及肽组氨酸异亮氨酸抗血清对气管平滑肌非肾上腺素能、非胆碱能舒张作用的影响。
Br J Pharmacol. 1989 Mar;96(3):513-20. doi: 10.1111/j.1476-5381.1989.tb11847.x.

本文引用的文献

1
Influence of tracheal contraction on relaxant effects in vitro of theophylline and isoprenaline.气管收缩对茶碱和异丙肾上腺素体外松弛作用的影响。
Br J Pharmacol. 1981 Sep;74(1):73-9. doi: 10.1111/j.1476-5381.1981.tb09956.x.
2
Vasoactive intestinal peptide: a possible transmitter of nonadrenergic relaxation of guinea pig airways.血管活性肠肽：豚鼠气道非肾上腺素能舒张的一种可能递质。
Science. 1980 Dec 12;210(4475):1252-3. doi: 10.1126/science.6254154.
3
A substance P antagonist inhibits vagally induced increase in vascular permeability and bronchial smooth muscle contraction in the guinea pig.P物质拮抗剂可抑制豚鼠迷走神经诱导的血管通透性增加和支气管平滑肌收缩。
Proc Natl Acad Sci U S A. 1983 Feb;80(4):1120-4. doi: 10.1073/pnas.80.4.1120.
4
Pharmacological characterization of the autonomous innervation of the guinea pig tracheobronchial smooth muscle.豚鼠气管支气管平滑肌自主神经支配的药理学特性
Acta Pharmacol Toxicol (Copenh). 1981 Aug;49(2):150-7. doi: 10.1111/j.1600-0773.1981.tb00884.x.
5
Chemical design of antagonists of substance P.P物质拮抗剂的化学设计
Acta Physiol Scand. 1981 Apr;111(4):505-6. doi: 10.1111/j.1748-1716.1981.tb06771.x.
6
Occurrence and distribution of VIP nerves in the nasal mucosa and tracheobronchial wall.血管活性肠肽神经在鼻黏膜和气管支气管壁中的发生与分布。
Acta Otolaryngol. 1978 Nov-Dec;86(5-6):443-8. doi: 10.3109/00016487809107524.