Physical factors and angiogenesis.

Angiogenesis consists of migration and mitosis of blood vessels and lymphatic endothelium. The control of angiogenesis is multifactorial, being determined by physical as well as chemical factors. The physical factors include contact, binding, scaffolds and barriers, attachment, spreading, lining and even phagocytosis. The vascular pattern in the skin suggests that epithelium is a principal influence on angiogenesis and that it may guide or obstruct the growth of its blood supply, using fibrin, collagen, elastin and ground substance as a means of exerting control. The hamster cheek pouch and the chorioallantoic membrane have been used to demonstrate that epithelium exerts both chemical and physical effects. There is a need for further investigation of mechanisms underlying the conversion of physical factors into chemical signals. They probably include the release of proteases or their inhibitors during the distortion of fibrillar material.