Ryan T J, Barnhill R L
Ciba Found Symp. 1983;100:80-94. doi: 10.1002/9780470720813.ch6.
Angiogenesis consists of migration and mitosis of blood vessels and lymphatic endothelium. The control of angiogenesis is multifactorial, being determined by physical as well as chemical factors. The physical factors include contact, binding, scaffolds and barriers, attachment, spreading, lining and even phagocytosis. The vascular pattern in the skin suggests that epithelium is a principal influence on angiogenesis and that it may guide or obstruct the growth of its blood supply, using fibrin, collagen, elastin and ground substance as a means of exerting control. The hamster cheek pouch and the chorioallantoic membrane have been used to demonstrate that epithelium exerts both chemical and physical effects. There is a need for further investigation of mechanisms underlying the conversion of physical factors into chemical signals. They probably include the release of proteases or their inhibitors during the distortion of fibrillar material.
血管生成包括血管和淋巴管内皮细胞的迁移和有丝分裂。血管生成的控制是多因素的，由物理因素和化学因素共同决定。物理因素包括接触、结合、支架和屏障、附着、铺展、衬里甚至吞噬作用。皮肤中的血管模式表明上皮细胞是血管生成的主要影响因素，它可能利用纤维蛋白、胶原蛋白、弹性蛋白和基质作为控制手段来引导或阻碍其血液供应的生长。仓鼠颊囊和绒毛尿囊膜已被用于证明上皮细胞具有化学和物理作用。有必要进一步研究物理因素转化为化学信号的潜在机制。它们可能包括在纤维状物质变形过程中蛋白酶或其抑制剂的释放。
