Banwell Paul E, Musgrave Melinda
Department of Plastic Surgery, Radcliffe Infirmary, Oxford and Odstock Burns, Wound Healing and Reconstructive Surgery Research Trust, Laing Laboratory, Salisbury District Hospital, Salisbury, UK.
Int Wound J. 2004 Jun;1(2):95-106. doi: 10.1111/j.1742-4801.2004.00031.x.
Topical negative pressure (TNP) therapy has emerged as a high-technology, microprocessor-controlled physical wound-healing modality. Complex effects at the wound-dressing interface following application of a controlled vacuum force have been documented. These include changes on a microscopic, molecular level and on a macroscopic, tissue level: interstitial fluid flow and exudate management, oedema reduction, effects on wound perfusion, protease profiles, growth factor and cytokine expression and cellular activity, all leading to enhanced granulation tissue formation and improved wound-healing parameters. Primary indications for clinical use have been documented and include traumatic wounds, open abdominal wounds, infected sternotomy wounds, wound bed preparation, complex diabetic wounds and skin-graft fixation. Whilst this therapy now forms an essential part of the wound healing armamentarium, extensive clinical trials are recommended to confirm efficacy and delineate its optimum use.
局部负压（TNP）疗法已成为一种高科技、微处理器控制的物理伤口愈合方式。在施加可控真空力后，伤口敷料界面会产生复杂的效应，这已得到证实。这些效应包括微观分子水平和宏观组织水平的变化：组织间液流动和渗出液管理、水肿减轻、对伤口灌注的影响、蛋白酶谱、生长因子和细胞因子表达以及细胞活性，所有这些都导致肉芽组织形成增强和伤口愈合参数改善。临床使用的主要适应症已得到证实，包括创伤性伤口、开放性腹部伤口、感染性胸骨切开伤口、伤口床准备、复杂糖尿病伤口和皮肤移植固定。虽然这种疗法现在已成为伤口愈合手段的重要组成部分，但建议进行广泛的临床试验以确认其疗效并确定其最佳用途。
