Hedelin H, Lundholm K, Teger-Nilsson A C, Peterson H I, Pettersson S
Eur Surg Res. 1983;15(6):312-6. doi: 10.1159/000128374.
A recently developed method for occlusion of fistulas with a fibrin clot initiated studies of the effects of deposited fibrin on granulation tissue formation. Perforated Teflon cylinders, empty or fibrin-filled, were implanted subcutaneously in rats for 2, 3 and 4 weeks and the composition of the ingrowing granulation tissue was followed by sequential biochemical analysis. The concentration of fat and water and the cellularity, measured as DNA concentration, were the same throughout the period studied in the granulation tissue from cylinders implanted empty and fibrin filled. After 2 weeks of implantation, the collagen concentration was higher in fibrin-filled cylinders than in cylinders implanted empty. The higher collagen concentration was explained by a higher proportion of mature collagen-synthesising cells. After 3 and 4 weeks of implantation there was no difference in the collagen concentration between cylinders implanted empty and fibrin filled.
一种最近开发的用纤维蛋白凝块封堵瘘管的方法引发了对沉积纤维蛋白对肉芽组织形成影响的研究。将空的或填充有纤维蛋白的多孔聚四氟乙烯圆柱体皮下植入大鼠体内2周、3周和4周，并通过连续生化分析跟踪生长中的肉芽组织的组成。在植入空圆柱体和填充纤维蛋白的圆柱体的肉芽组织中，在所研究的整个时间段内，脂肪和水的浓度以及以DNA浓度衡量的细胞密度是相同的。植入2周后，填充纤维蛋白的圆柱体中的胶原蛋白浓度高于植入空圆柱体中的。较高的胶原蛋白浓度是由成熟胶原蛋白合成细胞的比例较高所解释的。植入3周和4周后，植入空圆柱体和填充纤维蛋白的圆柱体之间的胶原蛋白浓度没有差异。
