Hedelin H, Bagge U, Grenabo L, Pettersson S
Scand J Plast Reconstr Surg. 1983;17(3):179-81. doi: 10.3109/02844318309013115.
A recently developed method for the occlusion of fistulas with a fibrin clot has stimulated studies concerning the effects of deposited fibrin on the formation of granulation tissue (g.t.). In this study the influence of artificially implanted fibrin on the biomechanical properties of developing g.t. was investigated in rats. Perforated Teflon cylinders either empty or fibrin filled, were implanted subcutaneously for two weeks. The g.t. from fibrin filled cylinders was found to adhere significantly better to the cylinder walls which is an important property in the case of fistula closure with fibrin. Mechanical testing, however, showed that the maximum load and the maximum strain were significantly higher in cylinders implanted empty. However, the collagen concentration was no higher in cylinders implanted empty suggesting that in the newly formed g.t. studied, factors other than the collagen concentration determined the strength of the tissue.
一种最近开发的用纤维蛋白凝块封堵瘘管的方法激发了有关沉积纤维蛋白对肉芽组织（g.t.）形成影响的研究。在本研究中，在大鼠身上研究了人工植入的纤维蛋白对正在发育的肉芽组织生物力学特性的影响。将空的或填充有纤维蛋白的穿孔聚四氟乙烯圆柱体皮下植入两周。发现来自填充纤维蛋白圆柱体的肉芽组织与圆柱体壁的粘附明显更好，这在用纤维蛋白封堵瘘管的情况下是一项重要特性。然而，力学测试表明，植入空圆柱体的最大负荷和最大应变明显更高。然而，植入空圆柱体的胶原蛋白浓度并不更高，这表明在所研究的新形成的肉芽组织中，除了胶原蛋白浓度之外的其他因素决定了组织的强度。
