Bialick R, Gill R, Berke G, Clark W R
J Immunol. 1984 Jan;132(1):81-7.
Fatty acids incorporated into cytotoxic T lymphocytes (CTL) during in vitro stimulation can enhance or inhibit the subsequent expression of cell-mediated cytotoxicity, depending on the class of fatty acid. Unsaturated fatty acids enhance cytolysis, whereas saturated fatty acids inhibit it. The effects of fatty acids on cytolysis can be mediated in the absence of cell division, thus eliminating relative clonal amplification or contraction as a basis for the observed effects. Nevertheless, the net result of fatty acid alteration is an increase (unsaturated fatty acids) or decrease (saturated fatty acids) in the frequency, in the treated immune population, of CTL capable of lysing target cells. These observations are best explained by a model in which fatty acid incorporated into cell membrane phospholipids results in a direct recruitment into or out of the pool of CTL within the immune population capable of lysing target cells under the conditions employed to assay cytotoxicity.
在体外刺激过程中掺入细胞毒性T淋巴细胞（CTL）的脂肪酸可增强或抑制随后细胞介导的细胞毒性表达，这取决于脂肪酸的类别。不饱和脂肪酸增强细胞溶解作用，而饱和脂肪酸则抑制该作用。脂肪酸对细胞溶解的影响可在无细胞分裂的情况下介导，从而排除了相对克隆扩增或收缩作为观察到的效应的基础。然而，脂肪酸改变的最终结果是，在经处理的免疫群体中，能够裂解靶细胞的CTL频率增加（不饱和脂肪酸）或降低（饱和脂肪酸）。这些观察结果最好用以下模型来解释：掺入细胞膜磷脂的脂肪酸导致在用于测定细胞毒性的条件下，直接招募进入或离开免疫群体中能够裂解靶细胞的CTL池。
