Lahti A, Oikarinen A, Viinikka L, Ylikorkala O, Hannuksela M
Acta Derm Venereol. 1983;63(5):425-7.
To study the role played by prostaglandins (PGs) in contact urticaria, concentrations of 13,14-dihydro-15-keto-PGF2 alpha, 6-keto-PGF1 alpha, and thromboxane B2, the stable metabolites of PGF2 alpha, prostacycline and thromboxane A2 were measured by radio-immunoassay of the fluid taken from suction blisters in 11 patients. The blisters were raised on contact urticarial reactions induced by benzoic acid. The effect of peroral indomethacin on contact urticaria from benzoic acid was studied in a further 14 dermatological patients. The levels of these prostanoids in the blister fluid of urticarial skin did not differ from those derived from control blisters raised on apparently normal skin. Premedication with indomethacin, 50 mg t.i.d., completely prevented contact urticarial reactions to benzoic acid in all patients.
为研究前列腺素（PGs）在接触性荨麻疹中所起的作用，通过放射免疫分析法测定了11例患者因苯甲酸诱发接触性荨麻疹反应后，从抽吸水疱中获取的液体里PGF2α、前列环素和血栓素A2的稳定代谢产物13,14 - 二氢 - 15 - 酮 - PGF2α、6 - 酮 - PGF1α和血栓素B2的浓度。另外，对14例皮肤科患者研究了口服吲哚美辛对苯甲酸所致接触性荨麻疹的影响。荨麻疹皮肤水疱液中这些类前列腺素的水平与取自外观正常皮肤的对照水疱中的水平并无差异。所有患者在预先服用50毫克吲哚美辛、每日三次后，均完全预防了对苯甲酸的接触性荨麻疹反应。
