Coverly J, Peters L, Whittle E, Basketter D A
Unilever Environmental Safety Laboratory, Sharnbrook, Bedford, UK.
Contact Dermatitis. 1998 Feb;38(2):90-5. doi: 10.1111/j.1600-0536.1998.tb05658.x.
Adverse skin reactions cover many types of response: toxic, irritant, allergic, urticarial, sensory, etc. The relationships between an individual's tendency to develop different types of skin response are not well-described. We examined whether those who perceive stinging might be more likely to experience urticarial, sensory and irritation reactions in skin. A panel of 86 volunteers was tested with 10% lactic acid in the nasolabial fold to assess their ability to perceive stinging. At the same time, their capacity to develop non-immunologic contact urticaria was evaluated using chemicals of different structural type and urticant ability: methyl nicotinate, benzoic acid, cinnamic acid, cinnamaldehyde and dimethyl sulfoxide (DMSO). DMSO was also used to assess sensory effects and skin irritation. 44 were classes as "stingers" and 42 as "non-stingers". The pattern of urticant reactivity in the stingers and non-stingers was essentially the same, with neat DMSO generating the strongest reactions in both groups. Sensory reactions to DMSO (stinging, itching, tingling or burning) were similar in stingers and non-stingers; although the former may have reacted more quickly, a smaller proportion reacted (64% versus 76%). The skin irritation response to DMSO was also identical in stingers and non-stingers and the intensity of the urticant response in an individual did not correlate with the intensity of their subsequent irritant reaction. In conclusion, this study demonstrated that an individual's ability to perceive skin stinging does not give a general indication of their susceptibility to other types of non-immunologic skin response. Indeed, there appeared to be little evidence of correlations between any of the skin effects studied.
毒性反应、刺激性反应、过敏性反应、荨麻疹性反应、感觉性反应等。个体发生不同类型皮肤反应的倾向之间的关系尚未得到充分描述。我们研究了那些感觉到刺痛的人是否更有可能出现皮肤荨麻疹、感觉性反应和刺激性反应。对86名志愿者在鼻唇沟处使用10%乳酸进行测试，以评估他们感知刺痛的能力。同时，使用不同结构类型和致荨麻疹能力的化学物质：烟酸甲酯、苯甲酸、肉桂酸、肉桂醛和二甲基亚砜（DMSO），评估他们发生非免疫性接触性荨麻疹的能力。DMSO还用于评估感觉效应和皮肤刺激性。44人被归类为“刺痛者”，42人被归类为“非刺痛者”。刺痛者和非刺痛者的荨麻疹反应模式基本相同，纯DMSO在两组中均产生最强反应。刺痛者和非刺痛者对DMSO的感觉反应（刺痛、瘙痒、刺痛或灼烧）相似；尽管前者可能反应更快，但反应的比例较小（64%对76%）。刺痛者和非刺痛者对DMSO的皮肤刺激性反应也相同，个体的荨麻疹反应强度与随后的刺激性反应强度无关。总之，本研究表明，个体感知皮肤刺痛的能力并不能总体表明他们对其他类型非免疫性皮肤反应的易感性。事实上，在所研究的任何皮肤效应之间似乎几乎没有相关性的证据。
